天然产物研究与开发 ›› 2016, Vol. 28 ›› Issue (增刊2): 184-187.doi: 10.16333/j.10016880.2016.S.002

• 研究论文 • 上一篇    下一篇

拟诺卡氏放线菌YIM 90087的发酵液化学成分研究

张孝龙1,潘芸1,李铭刚1,林婷婷1,丁章贵1,文孟良1,赵江源1,2*   

  1. 1云南大学云南省微生物研究所;2自然资源药物化学教育部重点实验室(云南大学),昆明 650091
  • 出版日期:2016-12-31 发布日期:2017-03-03

Secondary Metabolites from Cultures of Nocardiopsis sp.YIM 90087

ZHANG Xiaolong1,PAN Yun1,LI Minggang1,LIN Tingting1,DING Zhanggui1,WEN Mengliang1,ZHAO Jiangyuan1,2*   

  1. 1Yunnan Institute of Microbiology,Yunnan University; 2Key Laboratory of Medicinal  Chemistry for Natural Resource (Yunnan University),Ministry of Education,Yunnan University,Kunming 650091,China
  • Online:2016-12-31 Published:2017-03-03

摘要: 对拟诺卡氏菌YIM90087的液体发酵提取物进行了化学成分研究,从中分离得到10个化合物。通过波谱数据分析,鉴定其结构分别为: 4羟基苯甲醛(1)、2羟基1(1H吲哚3基)乙酮(2)、4羟基苯甲酸(3)、2氨基3甲氧基4甲基吡啶(4)、4,7双(4甲氧基苯基)6羟基5甲氧基苯并噻唑(5)、1(4甲基哌嗪1基)乙酮(6)、(3R,8aS)3异丙基六氢吡咯并[1,2a]吡嗪1,4二酮(7)、2(2氨基乙基)乙酸苯酯(8)、 N乙酰基酪胺(9)和6′羟基4,2′,3′,4′′四甲氧基对三联苯 (10)。化合物4目前只见化学合成报道,为新天然产物。

关键词: 拟诺卡氏菌, 液体发酵, 分离纯化, 结构鉴定

Abstract: The chemical constituents from the liquid fermentation of Nocardiopsis sp.YIM90087 were studied.ten compounds were isolated,and their structures were determined by spectral analysis as 4hydroxybenzaldehyde(1),2hydroxy1(1Hindol3yl)ethanone(2),4hydroxybenzoic acid(3),3methoxy4methylpyridin2amin(4),4,7Bis(4methoxyphenyl)6hydroxy5methoxybenzo[d]thiazole(5),1(4methylpiperazin1yl)ethanone(6),cyclo(LproLval)(7),2(2aminoethyl)phenyl acetate(8),Nacetyltyramine(9) and 6′Hydroxy4,2′,3′,4′′tetramethoxypterphenyl(10).Compound 4 was previously reported in chemical synthesis,and was a new natural product.

Key words: Nocardiopsis sp, liquid fermentation, isolation, structural elucidation

中图分类号: 

R379.1 58