天然产物研究与开发 ›› 2015, Vol. 27 ›› Issue (7): 1317-1323.doi: 10.16333/j.1001-6880.2015.07.033

• 综述 • 上一篇    

产虫草素真菌资源的研究现状及应用前景

买尔哈巴·艾合买提,古丽·艾合买提,杨新平*   

  1. 新疆农业科学院微生物应用研究所,乌鲁木齐 830091
  • 出版日期:2015-07-20 发布日期:2015-07-23

Present Situation and Application Prospect of Cordycepin-Production Fungus

Maierhaba·AIHEMAITI,Guli·AIHEMAITI,YANG Xin-ping*   

  1. Institute of Microbiology,Xinjiang Academy of Agriculture of Sciences,Xinjiang Urumqi 830091,China
  • Online:2015-07-20 Published:2015-07-23

摘要: 虫草素是中国传统中药冬虫夏草中特有活性成分,它具有抗肿瘤、抗病毒、调节免疫、治疗白血病等多种功效,作为一种新的抗菌素,虫草素已成为一个研究热点。人工合成虫草素过程复杂且产量极低,且会产生毒副产品,含有虫草素的天然材料稀少,高效率提取纯化工艺有待于优化。本文对虫草素的菌株来源、测定方法、提取方法、国内外研究现状及应用前景进行了总结,提出通过资源调查拓宽虫草素来源,找出虫草素合成酶活性更好的菌种,为降低生产成本、提高生物合成量,提供相应的基因和种质资源,为其进入更加广泛的使用范围奠定基础。

关键词: 虫草素, 蛹虫草, 真菌资源, 资源调查, 腺苷含量

Abstract: Cordycepin,the unique active ingredients in Chinese traditional medicine Cordyceps sinensis, is a hot spot nowadays due to its bio-activities,such as anti-tumor, anti-virus,immune regulation,treatment of leukemia, etc. Synthetic process of cordycepin is complex and low yield with toxic by-products.Natural resources of cordycepin is rare.The fungal sources,measurement,extraction,application prospect and the present research situation of cordycepin-production fungus at home and abroad were reviewed in this study.It was proposed to broaden the sources of cordycepin by resources investigation,to find out the strains which produce high cordycepin with lower cost,and to lay the ground for its more widespread usage.

Key words: cordycepin, Cordyceps militaris fungi resources, resources survey, adenosine content

中图分类号: 

S567.3+5