关键词: 岩木瓜, 化学成分, 蛋白酪氨酸磷酸酯酶1B

Abstract: Chemical investigation of the stem bark of Ficus tsiangii led to the isolation of 18 compounds by repeated chromatography methods,their structures were elucidated as 4′-hydroxyacetophenone (1),4-hydroxybenzoic acid (2),ethyl 4-hydroxybenzoate (3),3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-1-one (4),caffeic acid (5),ethyl caffeate (6),p-hydroxybenzaldehyde (7),methyl caffeoate (8),p-hydroxy-cinnamic acid (9),salicylic acid (10),protocatechuic acid (11),3,5-dihydroxy-4-methoxy-benzoicacid (12),4-glucosyranosyloxy-benzadehyde (13),tryptophan (14),stigmast-3,6-dione (15),β-sitostenone (16),5αstigmast-9(11)-en-3β-ol (17),and daucosterol (18) on basis of spectroscopic analyses.These compounds were isolated from the plant for the first time,and compounds 4,6,16,and 17 were isolated from the genus Ficus for the first time.The PTP1B inhibitory activity was evaluated for the 46 compounds isolated from the plant,11 compounds showed PTP1B inhibitory activity,displaying IC₅₀ values of 1.0-37.0 μM.

Key words: Ficus tsiangii, chemical constituents, PTP1B