天然产物研究与开发 ›› 2016, Vol. 28 ›› Issue (5): 775-780.doi: 10.16333/j.1001-6880.2016.5.025

• 开发研究 • 上一篇    下一篇

湖南黑茶对小鼠辐射损伤的保护作用

张广慧,吴红英,周则卫,张晓东,王浩,刘培勋*,龙伟*   

  1. 中国医学科学院北京协和医学院放射医学研究所,天津 300192
  • 出版日期:2016-05-28 发布日期:2016-09-06

Protective Effects of Hunan Dark Tea Against Radiation Injuries in Mice

ZHANG Guang-hui ,WU Hong-ying,ZHOU Ze-wei,ZHANG Xiao-dong, WANG Hao,LIU Pei-xun*, LONG Wei*   

  1. Institute of Radiation Medicine,Chinese Academy of Medical Science & Peking Union Medical College,Tianjin 300192,China
  • Online:2016-05-28 Published:2016-09-06

摘要: 研究湖南黑茶对辐射损伤小鼠的保护作用。本研究采用外周血液学指标、免疫系统指标、体内抗氧化指标超氧化物歧化酶(Superoxide dismutase,SOD)及存活时间考察黑茶对辐射损伤小鼠的保护作用。结果显示,小鼠受到137Cs-γ 6.5 Gy的照射后,与单纯照射组相比,黑茶能明显提高小鼠的外周血白细胞数(white blood cell ,WBC)、股骨有核细胞数(the number of bone narrow nucleated cells,BMNC)、骨髓DNA含量以及脾结节数(colony forming unit- spleen,CFU-S),差异具有显著性(P<0.05);小鼠受到137Cs-γ 6.0 Gy后,与单纯照射组相比,黑茶可显著提高小鼠肝组织和肺组织中SOD的活力,差异具有显著性(P<0.05);黑茶可使受照(8.0 Gy)小鼠存活天数由8.6±1.96 d延长到11.13±2.75 d。提示黑茶有较好辐射防护的作用。

关键词: 黑茶, 辐射损伤, 抗氧化, 抗辐射

Abstract: This study aimed to investigate the protective effect of Hunan Dark Tea against radiation injuries in mice. Peripheral blood index,immune system index,superoxide dismutase of anti-oxidative index and survival time estimation were used to observe the effect of Dark Tea to protect mice from radiation injuries. Compared with the irradiation-only group,the results showed that Dark Tea can effectively increase the white blood cell (WBC),the number of bone narrow nucleated cells (BMNC),DNA content of bone marrow and colony forming unit- spleen (CFU-S) of mice irradiated with 6.5 Gy γ-rays. The difference was significant (P<0.05). Besides,the SOD activities of the liver and lung tissue of mice irradiated with 6.0 Gy γ-rays in Dark Tea administrated group markedly increased when compared with irradiationonly group. The difference was significant (P<0.05);In addition,Dark Tea also prolonged the survival time of mice from 8.6±1.96 d to 11.13±2.75 d after irradiated with 8.0 Gy γ-rays. All these experimental results suggested that Dark Tea have good anti-radiation activities.

Key words: dark tea, radiation injury, anti-oxidation, anti-radiation

中图分类号: 

R932/R961.1