天然产物研究与开发 ›› 2017, Vol. 29 ›› Issue (1): 58-62.doi: 10.16333/j.1001-6880.2017.1.010

• 研究简报 • 上一篇    下一篇

彝药鬼吹箫的化学成分研究

向彩朋,王莹,王倩,冯阳,潘卉,许敏*,李海舟*   

  1. 昆明理工大学生命科学与技术学院,昆明 650500
  • 出版日期:2017-01-31 发布日期:2017-02-17

Chemical Constituents from Leycesteria formosa

XIANG Cai-peng,WANG Ying,WANG Qian,FENG Yang,PAN Hui,XU Min*,LI Hai-zhou*   

  1. Faculty of Life Science and Technology,Kunming University of Science and Technology,Kunming 650500,China
  • Online:2017-01-31 Published:2017-02-17

摘要: 采用凝胶树脂(Toyopearl HW-40c)、正相硅胶、反相硅胶(ODS)、大孔树脂(MCI)等柱层析方法从忍冬科鬼吹箫属植物鬼吹箫(Leycesteria formosa Wall.)的茎干部位分离得到8个化合物,包括1个降木脂素类(1)、2个黄酮类(4和5)、3个咖啡酸类(2、3和8)和2个三萜类(6和7)。运用波谱光谱学方法分别鉴定为:samwirin(1)、顺式咖啡酸(2)、反式咖啡酸(3)、木犀草素(4)、芹菜素(5)、3羟基齐墩果烷(6)、熊果酸(7)和咖啡酸甲脂(8)。化合物1、2、4和5均首次从该植物中分离得到。采用MTT法测试了化合物1对肺癌细胞株(A549)和肝癌细胞株(HepG2)2种人肿瘤细胞株的体外细胞毒活性,结果表明化合物1在40 μM浓度下对所测试的2种细胞株未显示细胞毒活性。

关键词: 鬼吹箫, 化学成分, 木脂素

Abstract: Eight compounds were isolated from the stems of Leycesteria formosa including one neolignan,two flavonoids,three caffeic acids and two triterpenoids.These compounds were identified as samwirin(1),cis-caffeic acid (2), trans-caffeic acid (3),luteolin(4),apigenin(5),3-ketooleanane (6),ursolic acid (7)and caffeic acid methyl ester (8),respectively.Compounds 1,2,4 and 5 were firstly isolated from L.formosa.In addition,the cytotoxic activities of 1 against A549 and HepG2 cell lines were investigated by MTT assay.The results showed that at the concentration of 40 μM,no cytotoxic activities were detected for 1 against A549 and HepG2 cell lines.

Key words: Leycesteria formosa, chemical constituents, lignans

中图分类号: 

R284.2