天然产物研究与开发 ›› 2017, Vol. 29 ›› Issue (1): 159-171.doi: 10.16333/j.1001-6880.2017.1.030

• 综述 • 上一篇    下一篇

海洋来源放线菌中新生物碱成分研究进展

郭娜燕1*,吕国荣1,2,邱丹缨1   

  1. 1泉州医学高等专科学校;2福建医科大学附属第二医院,泉州 362000
  • 出版日期:2017-01-31 发布日期:2017-02-17

Review on Alkaloids from Marine-derived Actinomycetes

GUO Na-yan1*,LV Guo-rong1,2,QIU Dan-ying1   

  1. 1 Quanzhou Medical College;2Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China
  • Online:2017-01-31 Published:2017-02-17

摘要: 因其独特的生活环境,海洋来源的放线菌具有新颖的代谢途径。近年来从海洋来源的放线菌分离出大量的生物碱,具有独特的化学结构与多种生物活性,有些已进入临床前研究。这些活性生物碱为药物研发提供了丰富的先导化合物。本文介绍了2010年以来国内外报道的海洋来源放线菌中新生物碱的化学结构、来源与生物活性,旨在对海洋来源放线菌生物碱的研究奠定基础。

关键词: 海洋, 放线菌, 生物碱, 进展

Abstract: Due to the unique living environment,marine-derived actinomycetes have novel metabolic pathways.In recent years,many alkaloids with remarkable activity and novel structure have been found from marine-derived actinomycetes,some of which have entered into the pre-clinical research.These active alkaloids provide tremendous lead compounds for drug discovery and development.In order to lay the foundation for the research of marine derived actinomycetes alkaloids,the chemical structure,source and biological activity of the new alkaloids from marine-derived actinomycetes since 2010 were introduced.

Key words: marine, actinomycetes, alkaloids, review

中图分类号: 

Q629.3