天然产物研究与开发 ›› 2017, Vol. 29 ›› Issue (5): 731-734.doi: 10.16333/j.1001-6880.2017.5.002

• 研究论文 • 上一篇    下一篇

多刺绿绒蒿中的一个新生物碱类化合物

常颜,王晓玲,唐晓莹,袁绿益,陈炼红*   

  1. 西南民族大学药学院,成都 610041
  • 出版日期:2017-05-31 发布日期:2017-06-09

A New Alkaloid from Meconopsis horridula

CHANG Yan,WANG Xiao-ling,TANG Xiao-ying,YUAN Lv-yi,CHEN Lian-hong*   

  1. Pharmacy College,Southwest Minzu University,Chengdu 610041,China
  • Online:2017-05-31 Published:2017-06-09

摘要: 多刺绿绒蒿在藏区是一种非常重要的民间用药。该植物中已发现多种生物碱,其中很多都具有显著的生物活性。用正相硅胶、ODS柱色谱从多刺绿绒蒿的地上部分分离得到了三个生物碱,根据其质谱、红外、核磁等波普数据鉴定结构,分别为(6a-S)-des-N-methyl-(+)-cryprochine(1),华紫堇碱(2)及原鸦片碱(3),其中化合物1为新化合物,化合物2为首次在该植物中分离得到。

关键词: 藏药, 多刺绿绒蒿, 生物碱, (6a-S)-des-N-methyl-(+)-cryprochine

Abstract: Meconopsis horridula is an important traditional Tibetan folk medicine.The plant has function of clearing internal heat and promoting blood circulation for removing blood stasis.It was used to treat fractures and bruises.Many alkaloids have been isolated from this species,most of which have significant bioactivities.In this study,the 95% alcohol extract from the aerial part of Meconopsis horridula was fractionated using open column chromatography with silica gel and ODS.Three alkaloids were isolated from the plant.A new proaorphine alkaloid,(6a-S)-des-N-methyl-(+)-cryprochine(1),together with two known alkaloids,cheilanthifoline(2) and protopine(3) were isolated and identified.Compound 2 was isolated from this plant for the first time.The structures of purified compounds were determined using spectroscopic methods including IR,MS,and 1D and 2D NMR,and by comparison with literature data for known alkaloids.

Key words: Tibetan medicine, Meconopsis horridula, alkaloid, (6a-S)-des-N-methyl-(+)-cryprochine