天然产物研究与开发 ›› 2017, Vol. 29 ›› Issue (5): 791-795.doi: 10.16333/j.1001-6880.2017.5.012

• 研究简报 • 上一篇    下一篇

光白英的化学成分研究

李萌,王戎博,崔燕,戴胜军,李桂生*   

  1. 烟台大学药学院,烟台 264005
  • 出版日期:2017-05-31 发布日期:2017-06-09

Chemical Constituents from Solanum borealisinense

LI Meng,WANG Rong-bo,CUI Yan,DAI Sheng-jun,LI Gui-sheng*   

  1. School of Pharmaceutical Science,Yantai University,Yantai 264005,China
  • Online:2017-05-31 Published:2017-06-09

摘要: 利用硅胶柱色谱、Sephadex LH-20柱色谱及高效制备薄层层析等手段对茄属植物光白英全草的化学成分进行分离纯化,根据化合物理化性质和波谱数据对其化学结构进行阐明,发现并鉴定了16个化合物,分别为:白英醇E(1)、白英醇 F(2)、白英醇A(3)、白英醇B(4)、白英醇C(5)、江西白英素A(6)、江西白英素D(7)、布卢门醇A(8)、去氢催吐萝芙醇(9)、3β-羟基-5α,6α-环氧-7-大柱香波龙烯-9-酮(10)、布卢门醇 C(11)、东莨菪内酯(12)、(1S,2R,5S,10R)-2-(1′,2′-dihydroxy -1′-methylethyl)-6,10-dimethylspiro[4,5]dec-6-en-8-one(13)、chakyunglupulin A(14)、9,10,13-三羟基-反-11-十八烯酸(15)、2-(1′,2′-dihydroxy-1′-methylethyl)-6,10-dimethyl-9-hydroxyspiro[4,5]dec-6-en-8-one(16)。化合物1~11、13、16为倍半萜;化合物1~16均为首次从光白英中发现。

关键词: 光白英, 化学成分, 倍半萜

Abstract: By means of column chromatography over silica gel,Sephadex LH-20 and preparative HPTLC.Sixteen compounds were isolated and purified from the whole plant of Solanum borealisinense. Their structures were elucidated on the basis of physico-chemical properties and spectral data as:lyratol E (1),lyratol F (2), lyratol A (3),lyratol B (4),lyratol C (5),solajiangxin A (6),solajiangxin D (7),blumenol A (8),dehydrovomifoliol (9),3β-hydroxy-5α,6α-epoxy-7-megastigmen-9-one (10),blumenol C (11),scopoletin (12),(1′S,2R,5S,10R)-2-(1′,2′-dihydroxy-1′-methylethyl)-6,10-dimethylspiro[4,5]dec-6-en-8-one (13),chakyunglupulinA (14),9,10,13-trihydroxy-(E)-11-octadecenoic acid (15),2-(1′,2′-dihydroxy-1′-methylethyl)-6,10-dimethyl-9-hydroxyspiro[4,5]dec-6-en-8-one (16).Compounds 1-11,13 and 16 were sesquiterpenoids.For the first time,compounds 1-16 were obtained from S.borealisinense.

Key words: Solanum borealisinense, chemical constituent, sesquiterpenoid