关键词: 文殊兰, 化学成分, 结构鉴定, 抗炎活性

Abstract: This paper reported the chemical constituents and anti-inflammatory activities of leaves of Crinum asiaticum var. sinicum,an herb for treatment of rheumatoid arthritis in Xishuangbanna Dai medicine.Thirteen compounds were isolated and purified from C. asiaticum var. sinicum by using column chromatography and identified by chemical and spectral analyses.Their structures were elucidated as 7,4′-dihydroxyflavan (1),7,4′-dihydroxy-8-methyl-flavan (2),farrerol (3),stigmast-4-ene-3β,6β-diol (4),byzantionoside B (5),daucosterol+stigmasterol-3-O-glucopyranoside (6),(6R,9R)-3-oxo-α-ionol-9-O-β-D-glucopyranoside (7),5-hydroxy-6,7-methylenedioxy-2-methylchromone (8),n-butyl-β-D-fructopyranoside (9),stigmasterol (10),stigmasterol-3-O-β-D-fructopyranoside (11),β-sitosterol (12),daucosterol (13),among which compounds 2-8 were obtained from this plant for the first time.Extracts from leaves of C. asiaticum var. sinicum showed significant NO inhibitory activities,i.e.anti-inflammatory activities,as well as compounds 7,4′-dihydroxy-8-methyl-flavan (2),farrerol (3),which enriched the study of  C. asiaticum var. sinicum and will be conducive to the exploiting of its medicinal value.

Key words: Crinum asiaticum var. sinicum, chemical constituents, structural identification, anti-inflammatory activities