关键词: 黄芪-苍术, 糖尿病肾病, 糖脂代谢, 网络药理学

Abstract: To explore the mechanism of Stragalus membranaceus (Fisch.)Bunge and Atractylodes lancea (Thunb.)DC.on improving glucose and lipid metabolism in diabetic kidney disease.Using network pharmacology method,effective active ingredients of S. membranaceus and A. lancea were screened out through Chinese medicine system pharmacology database (TCMSP),and potential targets related to diabetic kidney disease were screened out through Drug Bank,GeneCards,and OMIM databases.Active components to target network map were constructed using Cytoscape 3.6.1 software and Metascape database,and signaling pathways related to glucose and lipid metabolism were analyzed using KEGG and GO enrichment.Through screening,there were 29 effective active ingredients were founding in S. membranaceus and A. lancea ,such as quercetin,kaempferol,wogonin,isorhamnetin may participate in mTOR,insulin,adipocytokines and Jak-STAT signaling pathway,and it play a key role in regulating glucose and lipid metabolism by targeting PIK3CG,AKT1,MAPK1,IGF2.In summary,S. membranaceus and A. lancea  possess multi-component,multi-target and multiple pharmacological effects on improving glucose and lipid metabolism in diabetic kidney disease,and providing clues for further research on the treatment of diabetic kidney disease.

Key words: Stragalus membranaceus (Fisch.)Bunge. and Atractylodes lancea (Thunb.)DC., diabetic kidney disease, glucose and lipid metabolism, network pharmacology