石菖蒲挥发油中主要成分α-和β-细辛醚的神经药理学作用及机制研究进展

doi:10.16333/j.1001-6880.2020.11.021

天然产物研究与开发 ›› 2020, Vol. 32 ›› Issue (11): 1969-1979.doi: 10.16333/j.1001-6880.2020.11.021

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石菖蒲挥发油中主要成分α-和β-细辛醚的神经药理学作用及机制研究进展

徐飞飞1，李钦青1，楚世峰2，贺文彬1*

1山西中医药大学中医脑病学山西省重点实验室，太原 030624；2中国医学科学院药物研究所，北京 100050

出版日期:2020-11-28 发布日期:2020-12-07
基金资助:
国家自然科学基金（81473375）；山西省重点研发计划（国际科技合作）重大区域创新合作项目（201803D42 1006，201903D421018）；山西省回国留学人员科研资助项目（2013-134）

Research progress on the neuropharmacological effects and mechanisms about the main components α- and β-asarone in volatile oils of Acorus

XU Fei-fei1,LI Qin-qing1,CHU Shi-feng2,HE Wen-bin1*#br#

#br#

1 Shanxi Key Laboratory of Chinese Medicine Encephalopathy,Shanxi University of Chinese Medicine,Taiyuan 030619,China; 2Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,China

Online:2020-11-28 Published:2020-12-07

摘要/Abstract

摘要： 石菖蒲是我国一种药用历史悠久的传统中药。现代研究发现石菖蒲中含有挥发油类、黄酮类、生物碱类、氨基酸类及糖类等多种化学成分，其中挥发油类为主要活性成分，包括α-细辛醚、β-细辛醚等。研究表明α-细辛醚、β-细辛醚具有广泛的药理活性，极具开发价值。近年来，尤其在抗神经系统疾病的研究中，α-和β-细辛醚已经受到国内外学者的极大关注。本文通过对石菖蒲活性物质α-和β-细辛醚的神经药理作用进行总结归纳，重点探讨其在抗脑缺血再灌注损伤中的潜在机制，为深入研究与开发石菖蒲提供依据。

关键词: α-细辛醚, β-细辛醚, 神经系统疾病, 脑缺血再灌注损伤

Abstract:

Acorus tatarrinowii Schott is a traditional Chinese herbal with a long history of medicinal application. It had been found in modern research that it contains many chemical components such as volatile oils,flavonoids,alkaloids,aminoacids,and saccharides,among which volatile oils are the principal active components. α-Asarone and β-asarone,the effective ingredients of volatile oils,are considered to have great potential for drug development due to their extensive bioactivities. Furthermore,the effects of α-asarone and β-asarone on nervous system disorders have aroused great concern worldwidely. To further investigate and develop the neuropharmacological effects of α-asarone and β-asarone as well as A. tatarrinowii,we review and discuss their underlying mechanisms in cerebral ischemia injury and ischemia-reperfusion injury in this article.

Key words: α-asarone, β-asarone, nervous system diseases, cerebral ischemia-reperfusion injury

中图分类号: R285

徐飞飞, 李钦青, 楚世峰, 贺文彬. 石菖蒲挥发油中主要成分α-和β-细辛醚的神经药理学作用及机制研究进展[J]. 天然产物研究与开发, 2020, 32(11): 1969-1979.

XU Fei-fei, LI Qin-qing, CHU Shi-feng, HE Wen-bin. Research progress on the neuropharmacological effects and mechanisms about the main components α- and β-asarone in volatile oils of Acorus[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2020, 32(11): 1969-1979.

石菖蒲挥发油中主要成分α-和β-细辛醚的神经药理学作用及机制研究进展

Research progress on the neuropharmacological effects and mechanisms about the main components α- and β-asarone in volatile oils of Acorus

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