关键词: 姜黄素, 肿瘤, 卵巢癌, 信号通路, 靶点

Abstract:

To determine the pharmacokinetic parameters and anti-ovarian cancer effect of curcumin ,we predicted target genes against ovarian cancer of curcumin by STITCH database,DisGeNET database etc and we constructed and analyzed the protein-interactions network and key target KEGG pathways.We discovered that curcumin was consistent with the Five Principles of drug-like and property of gastrointestinal absorption,but was not consistent with the properties of blood-brain barrier and non-p-glycoprotein substrate.Curcumin play a multi-pathway anti-ovarian cancer pharmacological role via regulates 17 key ovarian cancer target genes included TP53, CASP3,EGFR,Erbb2,KT1,MTOR,STAT3,MMP2,MMP9,HIF1A,PTGS2,CCND1etc. and by regulating tumor angiogenesis,tumor invasion and metastasis,tumor cell apoptosis,tumor immunity,estrogen pathway,tumor cell proliferation and development of 6 categories of 16 signal pathway.

Key words: curcumin, tumor, ovarian cancer, signaling pathways, target