To investigate the mechanism of Resina Liquidambaris in the treatment of RA based on network pharmacology and molecular docking.According to TCMID platform and related literature,13 kinds of effective active ingredients of Resina Liquidambaris were required,and 27 target of active ingredients for RA treatment was searched from SwissTargetPrediction,TTD,NHGRI,GWAS database."Component-target network" and" target interaction network" was constructed based on Gephi software,which showed that Resina Liquidambaris play a role in the treatment of RA by acting on MAPK14,PTGS2 and other targets.Metascape was used for enrichment analysis of gene pathway.The results showed that Resina Liquidambaris play a role in the treatment of RA by acting on interleukin-2 related signal pathway and MAPK signal pathway,etc.After molecular docking of components and targets with LeDock,the higher docking scores are docking of M19 and CTSK,G6PD,MAPK14,PTGS2,M8 and G6PD,MAPK14,M6 and PTGS2,M23 and PTGS2.Therapeutic effect of Resina Liquidambaris on RA showed the characteristics of traditional Mongolian medicine as multi-components，multi-targets，and multi-pathways.