天然产物研究与开发 ›› 2024, Vol. 36 ›› Issue (9): 1625-1637.doi: 10.16333/j.1001-6880.2024.9.018

• 综述 • 上一篇    

天然萜类木脂素化学结构及药理作用研究进展

陈家毅,施冲煜,石宣宜,刘建群*   

  1. 江西中医药大学现代中药制剂教育部重点实验室,南昌 330004
  • 出版日期:2024-09-25 发布日期:2024-09-25
  • 基金资助:
    国家自然科学基金(82160731);江西中医药大学校级科技创新团队发展计划(CXTD22007)

Research progress on chemical structures and pharmacological effects of terpenoid lignans from natural sources

CHEN Jia-yi,SHI Chong-yu,SHI Xuan-yi,LIU Jian-qun*   

  1. Key Laboratory of Modern Preparation of Traditional Chinese Medicine,Ministry of Education,Jiangxi University of Chinese Medicine,Nanchang 330004,China
  • Online:2024-09-25 Published:2024-09-25

摘要: 萜类木脂素是自然界中一类由萜与木脂素骈合而成的天然化学成分,主要来源于木兰科木兰属和芸香科花椒属植物,按照结构特征主要可分为半萜木脂素、单萜木脂素、倍半萜木脂素三种类型。现代研究发现,萜类木脂素具有神经保护、抗肿瘤、抗炎、抗2型糖尿病、抗菌、抗氧化和杀虫等药理作用。本文对天然萜类木脂素的植物来源、结构类型以及药理作用进行了系统综述,以期为该类成分的进一步研究开发提供有益参考。

关键词: 天然萜类木脂素, 植物来源, 结构类型, 药理作用

Abstract:

Natural terpenoid lignans consist of terpenoid and lignan units,which are mainly found in Magnolia genus (Magnoliaceae) and Zanthoxylum genus (Rutaceae).Based on the structure,terpenoid lignans can be divided into three types:semiterpene lignans,monoterpene lignans and sesquiterpene lignans.Modern research show that terpenoid lignans possess various pharmacological effects such as neuroprotective,anti-tumour,anti-inflammatory,anti-type 2 diabetes,antibacterial,antioxidant and insecticidal.In this paper,the plant-derived,structural types and pharmacological effects of natural terpenoid lignans are systematically reviewed,which provide guidances for further research and development of terpenoid lignans.

Key words: natural terpenoid lignins, plant-derived, structure type, pharmacological effect

中图分类号:  R284 R285