天然产物研究与开发 ›› 2016, Vol. 28 ›› Issue (增刊2): 360-364.doi: 10.16333/j.10016880.2016.S.039

• 综述 • 上一篇    下一篇

白屈菜红碱的分离提取及生物学活性研究进展

邱东旭,李晓岩,赵敏*   

  1. 东北林业大学生命科学学院,哈尔滨 150040
  • 出版日期:2016-12-31 发布日期:2017-03-03

Review on Extraction and Biological Activities of Chelerythrine

QIU Dongxu,LI Xiaoyan,ZHAO Min*   

  1. College of Life Science,Northeast Forest University,Harbin,150040,China
  • Online:2016-12-31 Published:2017-03-03

摘要: 白屈菜为罂粟科白屈菜属植物,是一种有着很高开发前景的新型药用植物。白屈菜中的主要活性成分为白屈菜红碱,白屈菜红碱是一种苯并菲啶型生物碱,具有抗炎、抗菌等生物学活性。白屈菜红碱的分离提取方法很多,本论文介绍了微芯片电泳分离法、微波辅助萃取法、大孔吸附树脂等三种高效、省时的提取方法在白屈菜红碱分离提取中的应用。另外,本文还阐述了白屈菜红碱抗炎,抗菌,抗肿瘤和对胃溃疡保护的作用机理。本文将为以白屈菜红碱为先导物的生物活性物质的开发提供理论依据。

关键词: 白屈菜红碱, 生物学活性, 作用机理

Abstract: Chelidonium majus is a kind of very high prospects for the development of new medicinal plants.The main active ingredient of Chelidonium majus is chelerythrine.Chelerythrine is a benzo phenanthridine alkaloids and has antiinflammatory,antimicrobial and other biological activity.There were many methods to extract chelerythrine,this paper introduces three timesaving extraction methods for chelerythrine extraction such as microchip electrophoresis separation,microwave assisted extraction and macroporous adsorption resin.In addition,this paper describes the mechanism of chelerythrine in antiinflammatory,antibacterial,antitumor and protective effect on gastric ulcer.This paper will provide a theoretical basis for the development of chelerythrine as bioactive substances.

Key words: chelerythrine, biological activity, mechanisms

中图分类号: 

R284