南海链霉菌SCSIO 1635中抗霉素类化合物的分离鉴定

天然产物研究与开发 ›› 2011, Vol. 23 ›› Issue (1): 10-14.

南海链霉菌SCSIO 1635中抗霉素类化合物的分离鉴定

李苏梅，田新朋，牛四文，张文军，张偲，鞠建华，张长生^*

中国科学院南海海洋研究所海洋生物资源可持续利用重点实验室海洋微生物研究中心广东省海洋药物重点实验室，广州 510301

收稿日期:2010-05-10 发布日期:2011-07-20
通讯作者: czhang2006@gmail.com

Antimycins from Marine Streptomyces sp. SCSIO 1635 from the South China Sea

LI Su-mei, TIAN Xin-peng, NIU Si-wen, ZHANG Wen-jun, ZHANG Si, JU Jian-hua, ZHANG Chang-sheng^*

CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbiology, CAS,Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China

Received:2010-05-10 Published:2011-07-20
Supported by:
This research was supported by the Funds of the Chinese Academy of Sciences for Key Topics in Innovation Engineering (KZCX2-YW-216, KSCX2-YW-G-065, KSCX2-YW-G-073), Natural Science Funds of South China Sea Institute of Oceanology for Young Scholar (SQ200903), Funds of Frontier Areas of SCSIO (LYQY200805), Open Project Program of Key Laboratory of Marine Bio-resources Sustainable Utilization (LMB091013).

摘要/Abstract

摘要：

我们从南海海底沉积环境分离了一株放线菌SCSIO 1635，经16S rDNA的序列分析将该株菌鉴定为链霉菌属。我们从该菌的发酵液中分离得到了4个化合物，经质谱和核磁共振波谱解析，确定为抗霉素类化合物：异构体antimycin A_1a 和 A_1b（1）、deisovalerylblastmycin（2）、kitamycin A（3）和antimycin A₉（4）。

关键词: 南海沉积环境, 海洋放线菌, 海洋微生物天然产物, 链霉菌, 抗霉素

Abstract:

The strain SCSIO 1635 was isolated from marine sediment of the South China Sea, and identified as a member of Streptomyces according to the 16S rDNA sequence. Four compounds were isolated from Streptomyces sp. SCSIO 1635. The compounds were found to be structurally-related to antimycins by detailed analyses of MS and NMR spectroscopic data, and were identified as antimycin A_1a and A_1b (1), deisovalerylblastmycin (2), kitamycin A (3), and antimycin A₉ (4), respectively.

Key words: marine sediments of South China Sea, marine actinomycetes, marine microbial natural products, Streptomyces, antimycins

中图分类号:

Q936 R284.1

李苏梅，田新朋，牛四文，张文军，张偲，鞠建华，张长生. 南海链霉菌SCSIO 1635中抗霉素类化合物的分离鉴定[J]. 天然产物研究与开发, 2011, 23(1): 10-14.

LI Su-Mei, TIAN Xin-Peng, NIU Si-Wen, ZHANG Wen-Jun, ZHANG Cai, JU Jian-Hua, ZHANG Chang-Sheng. Antimycins from Marine Streptomyces sp. SCSIO 1635 from the South China Sea[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2011, 23(1): 10-14.

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