克班宁的镇痛作用部位及作用机制探讨

天然产物研究与开发 ›› 2011, Vol. 23 ›› Issue (2): 341-344.

克班宁的镇痛作用部位及作用机制探讨

林青^1*，杨莲¹，段小花¹，李秀芳^1,2，马云淑¹，代蓉¹

¹云南中医学院药理教研室，昆明650500；²上海中医药大学，上海201203

收稿日期:2009-12-08 出版日期:2011-04-25 发布日期:2011-10-14
通讯作者: Kmlinqing@yahoo.com.cn
基金资助:
云南省自然科学基金重点项目（2002C0006Z）

Site of Analgesic Action and Its Mechanism of Crebanine

LIN Qing^1* , YANG Lian¹, DUAN Xiao-hua¹, LI Xiu-fang^1,2 , MA Yun-shu¹, DAI Rong²

¹Yunnan University of Traditional Chinese Medicine, Kunming 650500, China; ²Shanghai University of Traditional Chinese Medicine, shanghai 201203, China

Received:2009-12-08 Online:2011-04-25 Published:2011-10-14

摘要/Abstract

摘要：

以探究克班宁的镇痛作用部位并初步明确其镇痛机制为目的。采用小鼠足趾注射甲醛法、热板法及腹腔注射醋酸（扭体法）所致疼痛模型，探讨克班宁的镇痛作用；以小鼠输精管经壁电刺激法，了解克班宁对吗啡受体的影响。结果发现克班宁在3.2 mg/kg时对三种疼痛模型均显示明显的抑制作用，并能明显抑制小鼠输精管经壁电刺激所引起的收缩，且该收缩不能被纳络酮所拮抗。因此，克班宁可能具有中枢样镇痛作用，但作用机制与吗啡受体无关。

关键词: 克班宁, 镇痛, 吗啡受体

Abstract:

The main aim was to determine the site of analgesic action and the mechanism of crebanine. The pain animal models of mouse toe injection of formaldehyde，hot plate test and writhing test were used. Mouse vas deferentia electrostimulation test was used to study the effect on morphine receptor of crebanine. As a result，the significant analgesic action of crebanine (3.2 mg/kg) was observed in three animal pain models. Moreover，crebanine could strongly inhibit the contraction of vas deferentia induced by electrical stimulation. The effect was not antagonized by naloxone. Crebanine had a central-like analgesic effect，and its mechanism was independent of the morphine-receptor.

Key words: crebanine, analgesic effect, morphine receptor

林青，杨莲，段小花，李秀芳，马云淑，代蓉. 克班宁的镇痛作用部位及作用机制探讨[J]. 天然产物研究与开发, 2011, 23(2): 341-344.

LIN Qing, YANG Lian, DUAN Xiao-Hua, LI Xiu-Fang, MA Yun-Shu, DAI Rong. Site of Analgesic Action and Its Mechanism of Crebanine[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2011, 23(2): 341-344.

参考文献

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