九节属药用植物化学成分及药理作用研究进展

摘要/Abstract

摘要：

九节属植物（Psychotria）是我国南方常用中草药。文献调研表明，关于我国境内本属植物相关化学成分及药理作用研究报道很少。为进一步研究开发Psychotria属药用植物资源，对其化学成分及药理作用进行综述，为其深入开发打下基础。

Abstract:

Plants from the genus of Psychotria were wildly used as folk medicines in the South China, however the reports on chemical constituents and bioactivities obtained from China were very few. In order to further study the chemical constituents from Genus of Psychotria and enlarge the sources of medicinal plants, a review on chemical constituents and bioactivities on genus Psychotria was finished.

Key words: Psychotria, chemical constituents, bioactivities

中图分类号:

R284 R285

张翠仙，彭光天，何细新，祝晨蔯，邓洁薇，韦瑀龙. 九节属药用植物化学成分及药理作用研究进展[J]. 天然产物研究与开发, 2011, 23(3): 571-576.

ZHANG Cui-xian,PENG Guang-tian,HE Xi-xin,ZHU Chen-chen,DENG Jie-wei,WEI Yu-long. Progress in Chemical Constituents and Bioactivities of Psychotria[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2011, 23(3): 571-576.

参考文献 64

1	Delectis Florae Reipublicase Pepularis Sinicase Agendae Acdemiae Sinicase Edita.Flora Reipublicase Popularis Sinicase,Vol.72(中国植物志) .Beijing:Science and Technology Press,2004.47-61.
2	Jiangsu New Medical College(江苏新医学院).Chinese TraditionalMedicine Dictionary(中药大辞典).Shanghai:Shanghai Science and Technology Press,1985.173-174.
3	State Administration of Traditional Chinese Medicine of the People’s Republic of China.Zhonghua Bencao.Shanghai: Shanghai Press of Science and Technology,1999.466-467.
4	Editorial board of National Chinese Medicine Assembly(《全国中草药汇编》编写组).National Chinese Medicine Assembly(《全国中草药汇编》).Beijing:People's Medical Publishing House,1975.1:100,2:810.
5	Guangdong Food and Drugs Administration(广东省食品药品管理局编著).Standard of Traditional Chinese Medicine of Guangdong,Vol.1(广东省中药材标准).Guangdong:Guangdong Science and Technology Press,2004.12-14.
6	Hayashi T,Smith FT,Lee KH,et al.Antitumor agents.89.Psychorubrin,a new cytotoxic naphthoquinone from Psychotria rubra and its structure-activity relationships.J Med Chem,1987,30:2005-2008.
7	Lee KH,Lin Yuh M,Wu TS,et al.Antitumor agents.LXXXVIII.The cytotoxic principles of Prunella vulgaris,Psychotria serpens,and Hyptis capitata: ursolic acid and related derivatives.Planta Med,1988,54:308-311.
8	Kuo YC,Chen CC,Tsai WJ,et al Regulation of herpes simplex virus type 1 replication in Vero cells by Psychotria serpens: relationship to gene expression,DNA replication,and protein synthesis.Antiviral Res,2001,51(2):95-109.
9	Hui WH,Yee CW.Rubiaceae of Hong Kong.III.Phytochemistryistry,1967,6:441-442.
10	Ohsugi M,Fan W,Hase K,et al.Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra.J Ethnopharm,1999,67:111-119.
11	Schultes RE,Raffauf RF.The Healing Forest.Portland,OR:Dioscorides Press,1990.392-396.
12	Glinski JA,David E,Warren TC,et al.Inactivation of cell surface receptors by pheophorbide,a green pigment isolated from Psychotria acuminata.Photochem Photobio,1995,62:144-150.
13	Dan S,Dan SS.Phytochemistryical study of Adansonia digitata,Coccoloba excoriata,Psychotria adenophylla and Schleichera oleosa.Fitoterapia,1986,57: 445-446.
14	Kerber VA,Gregianini TS,Paranhos JT,et al.Brachycerine,a novel monoterpene indole alkaloid from Psychotria brachyceras.J Nat Prod,2001,64:677-679.
15	Leal MB,Elisabetsky E.Opioid-like activity of Psychotria brachypoda.Int J Pharmacog,1996,34:267-272.
16	Dohnal B,Diak J,Stojakowska A.Cultivation and preliminary phytochemical analysis of the Psychotria bacteriophila callus tissue.Acta Poloniae Pharm,1989,46:401-403.
17	Paul JHA,Maxwell AR,Reynolds WF.Novel bis(monoterpenoid) indole alkaloids from Psychotria bahiensis.J Nat Prod,2003,66:752-754.
18	Hart NK,Johns SR,Lamberton JA,et al.Psychotridine,a C55H62N10 alkaloid from Psychotria beccarioides(Rubiaceae).Aust J Chem,1974,27:639-646.
19	Elisabetsky E,Amador TA,Albuquerque RR,et al.Analgesic activity of Psychotria colorata(Willd.ex R.& S.) Muell.Arg.Alkaloids.J Ethnopharm,1995,48:77-83.
20	Verotta L,Pilati T,Tato M,et al.Pyrrolidinoindoline alkaloids from Psychotria colorata.J Nat Prod,1998,61:392-396.
21	Amador TA,Elisabetsky E,Onofre SD.Effects of Psychotria colorata alkaloid in brain opioid system.Neurochem Res,1996,21(1):97-102.
22	Achenbach H,Lottes M,Waibel R,et al.Alkaloids and other compounds from Psychotria correae.Phytochemistry,1995,38: 1537-1545.
23	Düsman LT,Jorge TCM,Souza MC,et al.A novel anti-HIV macrocyclic peptide from Palicourea condensata.J Nat Prod,2004,67:1886-1888.
24	Solis PN,Lang'at C,Gupta MP,et al.Bio-active compounds from Psychotria camponutans.Planta Med,1995,61(1):62-65.
25	Leal MB,Elisabetsky E.Absence of alkaloids in Psychotria carthagenensis Jacq.(Rubiaceae).J Ethnopharm,1996,54(1):37-40.
26	Caballero GC,Vanderheyden PM,Solis PN,et al.Biological screening of selected medicinal Panamanian plants by radioligand-binding techniques.Phytomed: Int J Phytother phytopharm,2001,8(1):59-70.
27	Adjibade Y,Weniger B,Quirion JC,et al.Dimeric alkaloids from Psychotria forsteriana.Phytochemistry,1992,31:317-319.
28	Adjibade Y,Kuballa B,Cabalion P,et al.Cytotoxicity on human leukemic and rat hepatoma cell lines of alkaloid extracts of Psychotria forsteriana.Planta Med,1989,55:567-568.
29	Roth A,Kuballa B,Cabalion P,et al.Preliminary study of the alkaloids of Psychotria forsteriana.Planta Med,1985,(3):289.
30	Roth A,Kuballa B,Bounthanh C,et al.Cytotoxic activity of polyindoline alkaloids of Psychotria forsteriana(Rubiaceae)(1).Planta Med,1986,(6):450-453.
31	Beretz A,Roth GA,Corre G,et al.Polyindolinic alkaloids from Psychotria forsteriana.Potent inhibitors of the aggregation of human platelets.Planta Med,1985,(4):300-303.
32	Solis P,Ravelo AG,Palenzuela JA,et al.Quinoline alkaloids from Psychotria glomerulata.Phytochemistry,1997,44:963-969.
33	Jayasinghe ULB,Jayasooriya CP,Bandara BMR,et al.Antimicrobial activity of some Sri Lankan Rubiaceae and Meliaceae.Fitoterapia,2002,73:424-427.
34	Locher CP,Burch MT,Mower HF,et al Anti-microbial activity and anti-complement activity of extracts obtained from selected Hawaiian medicinal plants.J Ethnopharm,1995,49(1):23-32.
35	Muhammad I,Dunbar DC,Khan SI,et al.Antiparasitic alkaloids fromPsychotria klugii.J Nat Prod,2003,66:962-967.
36	Ame´ lia TH,S?´lvia OL,Juc ara TP,et al.N,b-D-Glucopyranosyl vincosamide,a light regulated indole alkaloidfrom the shoots of Psychotria leiocarpa.Phytochemistry,2004,65:449-454.
37	Witherup KM,Bogusky MJ,Anderson PS,et al.Cyclopsychotride A,a biologically active,31-residue cyclic peptide isolated from Psychotria longipes.J Nat Prod,1994,57:1619-1625.
38	Valerie J,Francoise G,Olivier L,et al.Pyrrolidinoindoline alkaloids from Psychotria oleoides and Psychotria lyciiflora.J Nat Prod,1999,62:838-843.
39	Gonzalez J,Dieck T.Asperuloside,an iridoid glucoside isolated from Psychotria mariniana.Revista Latinoamericana de Quimica,1996,24(1):7-9.
40	Khan MR,Kihara M,Omoloso AD.Antimicrobial activity of Psychotria microlabastra.Fitoterapia,2001,72:818-821.
41	Verotta L,Peterlongo F,Elisabetsky E,et al.High-performance liquid chromatography-diode array detection-tandem mass spectrometry analyses of the alkaloid extracts of Amazon Psychotria species.J Chrom A,1999,841:165-176.
42	Rasolonjanahary R,Sevenet T,Gueritte VF.Psycholeine,a natural alkaloid extracted from Psychotria oleoides,acts as a weak antagonist of somatostatin.Eur J Pharm,1995,285(1): 19-23.
43	Francoise GV,Thierry S,Jacques P,et al.Alkaloids from Psychotria oleoides with activity on growth hormone release.J Nat Prod,1992,55:923-930.
44	Lajis NH,Mahmud Z,Toia RF.The alkaloids of Psychotria rostrata.Planta Med,1993,59:383-384.
45	Mahmud Z,Musa M,Ismail N,et al.Cytotoxic and bactericidal activities of Psychotria rostrata.Int J Pharm,1993,31(2):142-146.
46	Benevides PJC,Young MCM,Bolzani V da S.Biological activities of constituents from Psychotria spectabilis.Pharmaceut Biol,2004,42:565-569.
47	Van DL,Fett-Neto AG,Kerber VA,et al.Indole monoterpene alkaloids from leaves of Psychotria suterella Mull.Arg.(Rubiaceae).Biochem System Ecol,2001,29:1185-1187.
48	Kerber VA,Passos CS,Verli H,et al.Psychollatine,a glucosidic monoterpene indole alkaloid from Psychotria umbellate.J Nat Prod,2008,71:697-700.
49	Callaway JC,Brito GS,Neves ES.Phytochemistryical analyses of Banisteriopsis caapi and Psychotria viridis.J Pychoact Dugs,2005,37:145-150.
50	Hiromitsu T,Ikue M,Mariko K,et al.New type of trimeric and pentameric indole alkaloids from Psychotria rostrata.Org Lett,2004,6:2945-2948.
51	Yohei M,Mariko K,Hiromitsu T.First total synthesis of trimeric indole alkaloid,psychotrimine.Org Lett,2008,10:125-128.
52	Gregianini TS,Silveira VC,Porto DD,et al.The alkaloid brachycerine is induced by ultraviolet radiation and is a singlet oxygen quencher.Photochem Photobiol,2003,78:470-474.
53	Gregianini TS,Porto DD,Nascimento NCD,et al.Environmental and ontogenetic control of accumulation of brachycerine,a bioactive indolle alkaloid from Psychotria brachyceras.J Chem Ecol,2004,30:2023-2036.
54	Nepokroeff M,Bremer B,Sytsma K.Reorganization of the genus Psychotria and tribe Psychotrieae(Rubiaceae) inferred from ITS and rbcL sequence data.Syst Bot,1999,24:5-27.
55	Lopes S,von Poser GL,Kerber VA,et al.Taxonomic significance of alkaloids and iridoid glucosides in the tribe Psychotrieae(Rubiaceae).Biochem Syst Ecol,2004,32:1187-1195.
56	Carlini EA.Plants and the central nervous system.Pharmacol Biochem Behav,2003,75:501-512.
57	Freedland CS,Mansbach RS.Behavioral profile of constituents in ayahuasca,an Amazonian psychoactive plant mixture.Drug Alcohol Depend,1999,54:183-194.
58	Riba J,Valle M,Urbano G,et al.Human pharmacology of ayahuasca: Subjective and cardiovascular effects,monoamine metabolite excretion,and pharmacokinetics.J Pharm Exp Therap,2003,306(1):73-83.
59	Rivier L,Lindgren JE."Ayahuasca",the South American hallucinogenic drink ethnobotanical and chemical investigation.Econ Bot,1972,26(2):101-129.
60	Murillo R,Castro V.Isolation of the alkaloid harmane from Psychotria suerrensis.Ing Cienc Quim,1998,18(2):61-62.
61	Macbride JF.In Flora of Peru;Dahlgren BE,Ed,Field Museum of Natural History,Botanical Series:Chicago,1936,Vol.13,Part 6,No.1,pp3-261.
62	Itoh A,Ikuta Y,Baba Y,et al.Ipecac alkaloids from Cephaelis acuminata.Phytochemistry,1999,52:1169-1176.
63	Itoh A,Tanahashi T,Nagakura N,et al.Tetrahydroisoquinoline-monoterpene glucosides from Alangium lamarckii and Cephaelis ipecacuanha.Phytochemistry,1994,36:383-387.
64	Itoh A,Tanahashi T,Nagakura N.Six tetrahydroisoquinoline-monoterpene glucosides from Cephaelis ipecacuanha.Phytochemistry,1991,30:3117-3123.

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