天然产物研究与开发 ›› 2014, Vol. 26 ›› Issue (12): 2082-2087.

• 综述 • 上一篇    

半边旗有效成分5F抗肿瘤作用研究进展

叶华1,梁念慈1,2,郑学宝1*   

  1. 1 广东医学院 广东天然药物研究与开发重点实验室;2 广东医学院生物化学与分子生物学研究所,湛江 524023
  • 出版日期:2014-12-31 发布日期:2015-01-09

Progress in Research on Anti-tumor Effect of 5F Isolated from Pteris semipinnata L.

YE Hua1, LIANG Nian-ci1,3, ZHENG Xue-bao1*   

  1. 1 Guangdong Key Laboratory for Research and Development of Natural Drugs,Guangdong Medical College,Zhanjiang 524023,China; 2 Institute of Biochemistry and Molecular Biology,Guangdong Medical College,Zhanjiang 524023,China
  • Online:2014-12-31 Published:2015-01-09

摘要: 半边旗为我国南方常用中草药,从中提取的有效成分5F具有良好的抗肿瘤作用。本文从体内外抗肿瘤药效、细胞凋亡、细胞周期、NF-κB通路、p53、ROS、MAPK通路以及肿瘤侵袭和转移等多方面综述近二十年来5F抗肿瘤作用研究概况和研究进展。

关键词: 半边旗, 5F, 抗肿瘤

Abstract: PsL(Pteris Semipinnata L.),is a common used herb in southern China.5F extracted from the PsL has good anti-tumor effect.This paper is to sum up the research progress of anti-tumor effect of 5F,from the aspects of anti-tumor efficacy in vitro and in vivo, apoptosis,cell cycle,NF-κB pathway, p53,ROS,MAPK pathway,tumor invasion and metastasis.

Key words: Pteris semipinnata L., 5F, anti-tumor

中图分类号: 

R285.5