天然产物研究与开发 ›› 2014, Vol. 26 ›› Issue (9): 1339-1344.

• 研究论文 •    下一篇

藁本内酯的稳定性及其主要转化产物研究

房鑫,熊智,林晓,冯怡,沈岚,梁爽*   

  1. 上海中医药大学 教育部中药现代制剂技术工程研究中心,上海 201203
  • 出版日期:2014-09-30 发布日期:2014-11-02

Study on the Stability of Ligustilide and Its Main Transformation Products

FANG Xin, XIONG Zhi, LIN Xiao, FENG Yi, SHEN Lan, LIANG Shuang*   

  1. Shanghai University of Traditional Chinese Medicine Engineering Research Center of Modern Preparation Technology of TCM, Ministry of Education,Shanghai 201203, China
  • Online:2014-09-30 Published:2014-11-02

摘要: 藁本内酯是川芎和当归的主要有效成分,其化学结构的不稳定性限制了它的进一步研究和临床应用。本实验通过色谱方法对其室温静置一个月后的产物进行制备,得到了14个藁本内酯的转化产物,并通过ESI-MS、NMR等光谱分析法确定了其结构,包括一个新化合物7′-carboxyl-wallichilide(1)。利用LC-MS峰面积归一化法,确定了藁本内酯及其转化产物的相对含量,阐明了藁本内酯的主要转化产物为其二聚体。

关键词: 藁本内酯, 稳定性, 转化产物

Abstract: Ligustilide is one of main active components from Rhizoma Chuanxiong and Radix Angelicae Sinensis. However, the instability of ligustilide limits its further research and application in clinics.In this study,the transformation products of ligustilide were prepared,after one month at room temperature,by conventional chromatography and spectroscopic methods.Fourteen transformation products were obtained and elucidated,which included a new dimerphthalide,namely,7′-carboxyl-wallichilide (1).The relative contents of ligustilide and its fourteen transformation products were determined by area normalization using LC-MS.The results showed that ligustilide dimers were the main transformation products of ligustilide.

Key words: ligustilide, stability, transformation products

中图分类号: 

R284.1