天然产物研究与开发 ›› 2014, Vol. 26 ›› Issue (9): 1492-1496.

• 开发研究 • 上一篇    下一篇

倒卵叶五加多糖的乙酰化工艺研究

赵 鹏*,张婷婷,宋 逍   

  1. 陕西中医学院药学院,咸阳 712046
  • 出版日期:2014-09-30 发布日期:2014-11-02

Study on Synthesis of Acetylation Derivatives of Acanthopanax obouatus  Hoo Polysaccharides

ZHAO Peng*, ZHANG Ting-ting, SONG Xiao   

  1. School of Pharmacy,Shaanxi University of Chinese Medicine,Xianyang 712046,China
  • Online:2014-09-30 Published:2014-11-02

摘要: 本文采用响应面法研究了倒卵叶五加多糖乙酰化的最优合成工艺,以多糖乙酰化的取代度为评价指标,考察了反应时间、乙酸酐与多糖的摩尔比和反应温度对多糖乙酰化取代度的影响。通过响应面法得到的最优工艺条件为:反应3.0 h,配料比3.7,反应温度70 ℃。初步的抗氧化性实验表明,乙酰化后的倒卵叶五加多糖的抗氧化性能有了明显提高。

关键词: 倒卵叶五加, 多糖, 乙酰化, 响应面, 抗氧化性

Abstract: The preparation of acetylation derivatives of Acanthopanax obouatus Hoo polysaccharides was studied.The influences of reaction time,ratio of polysaccharides-to-acetic anhydride and reaction temperature on the degree of substitution (DS) were studied by response surface methodology (RSM).The optimal conditions were reaction time of 3.0 h,ratio of polysaccharides-to-acetic anhydride of 3.7 and reaction temperature of 70 ℃.Compared with A.obouatus polysaccharides,the antioxidant ability of acetylation derivatives was improved.

Key words: Acanthopanax obouatus Hoo, polysaccharides, acetylation, response surface methodology, antioxidant ability

中图分类号: 

R283.6