天然产物研究与开发 ›› 2014, Vol. 26 ›› Issue (9): 1531-1537.

• 综述 • 上一篇    下一篇

半夏属植物凝集素的研究进展

赵 欢,彭正松*   

  1. 西华师范大学生命科学院,南充637002
  • 出版日期:2014-09-30 发布日期:2014-11-02

Review on Studies of Agglutinins in Pinellia

ZHAO Huan, PENG Zheng-song*   

  1. Life Science College of China West Normal University,Sichuan Nanchong,637002 ,China
  • Online:2014-09-30 Published:2014-11-02

摘要: 半夏属植物凝集素是一类能专一性结合甘露糖的糖蛋白,均含3个甘露糖结合位点和2个保守的B-lectin结合域,其氨基酸序列相似性较高,且二级结合和三维结构极为相似,具有抗虫、抗菌、抗肿瘤和凝血等生物学活性。本文从分离纯化、分子结构、系统进化、基因组织表达、生物学功能等方面对其进行了综述,以期为半夏属植物凝集素的深入研究及开发利用提供参考依据。

关键词: 半夏属植物凝集素, 分离纯化, 分子结构, 系统进化, 基因组织表达, 生物学功能

Abstract: Pinellia agglutinins are a group of glycoproteins that can specially bind to mannose.This gene family contained two conservative B-lectin domains and three mannose binding sites.The sequence comparison and three-dimensional structures showed Pinellia agglutinin genes had high similarity to each other.It has many important biological functions,such as anti-insect,anti-fungi,antineoplastic and haemagglutinins activities.In this paper,we provide an overview on Pinellia agglutinins with their purification,molecular structure,phylogenenic evolution,tissue expression and biological function.In addition,this review may ultimately help biologists to exploit Pinellia agglutinins in the future.

Key words: Pinellia Agglutinin, purification, molecular structure, phylogenenic evolution, tissue expression, biological function

中图分类号: 

R931.71