Box-Behnken优化痹痛宁凝胶膏剂基质处方研究

doi:10.16333/j.1001-6880.2015.02.006

天然产物研究与开发 ›› 2015, Vol. 27 ›› Issue (2): 226-231.doi: 10.16333/j.1001-6880.2015.02.006

Box-Behnken优化痹痛宁凝胶膏剂基质处方研究

李智1，于金英2,3，蒋瑶3，严倩茹2，王云红3，韩丽2，秦剑4，杨荣平2,3*

1 成都第一骨科医院，成都 610031；2 成都中医药大学，成都 611137；3 重庆市中药研究院，重庆 400065；4 重庆市食品药品检验所，重庆 401121

出版日期:2015-02-15 发布日期:2015-02-15

Optimization of Matrix Recipe of Bitongting Cataplasm by Box-Behnken Design

LI Zhi1, YU Jin-ying2,3, JIANG Yao3, YAN Qian-ru2, WANG Yun-hong3, HAN Li2, QIN Jian4, YANG Rong-ping2,3*

1 Number One Orthopedic Hospital of Chengdu,Chengdu 610031,China; 2 Chengdu University of Traditional Chinese Medicine(TCM),Chengdu 611137,China;3 Chongqing academy of Chinese Traditional Materia Medica,Chongqing 400065,China; 4 Chongqing Institute for Food and Drug Control,Chongqing 401121，China

Online:2015-02-15 Published:2015-02-15

摘要/Abstract

摘要： 利用Box-Behnken设计，以初黏力为评价指标，对凝胶膏剂处方进行优选。优选出痹痛宁凝胶膏剂基质的最佳处方为聚丙烯酸钠:高岭土:甘氨酸铝:柠檬酸=1.1:1.3:0.09:0.14，最佳处方的初黏力平均值为3.30 cm，与预测值的平均相对误差为2.30%。表明Box-Behnken设计适用于痹痛宁凝胶膏剂基质处方的优化，优化出的最佳处方具有较好的初黏力，为痹痛宁凝胶膏剂的开发奠定了基础。

关键词: Box-Behnken设计, 凝胶膏剂, 处方

Abstract: Taking the early adhesion as evaluation indexes to optimize the prescription of Bitongting Cataplasm by Box-Behnken design.The optimal ratioof the prescription of Bitongting Cataplasm was as follows:PAAS:Kaolin:Aluminum glycinate :Citric acid =1.1:1.3:0.09:0.14.The optimal prescription showed that the average value of early adhesion was 3.30 cm,and the average relative error value was 2.30%.The optimal prescription had good early adhesive.It is indicated that Box-Behnken design was suitable for the optimization of Bitongting Cataplasm prescription.This study provided the foundation for the development of new prescription of Bitongting Cataplasm.

Key words: Box-Behnken design, cataplasm, prescription

中图分类号:

R944.2+1

李智1，于金英2,3，蒋瑶3，严倩茹2，王云红3，韩丽2，秦剑4，杨荣平2,3*. Box-Behnken优化痹痛宁凝胶膏剂基质处方研究[J]. 天然产物研究与开发, 2015, 27(2): 226-231.

LI Zhi1, YU Jin-ying2,3, JIANG Yao3, YAN Qian-ru2, WANG Yun-hong3, HAN Li2, QIN Jian4, YANG Rong-ping2,3*. Optimization of Matrix Recipe of Bitongting Cataplasm by Box-Behnken Design[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2015, 27(2): 226-231.

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Box-Behnken优化痹痛宁凝胶膏剂基质处方研究

Optimization of Matrix Recipe of Bitongting Cataplasm by Box-Behnken Design

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