天然产物研究与开发 ›› 2015, Vol. 27 ›› Issue (7): 1296-1307.doi: 10.16333/j.1001-6880.2015.07.031

• 综述 • 上一篇    下一篇

忍冬属植物中环烯醚萜苷类化合物的研究进展

杜芳黎,姚彩云,宋志军   

  1. 广西壮族自治区药用植物园 西南濒危药材资源开发国家工程实验室,南宁 530023
  • 出版日期:2015-07-20 发布日期:2015-07-23

Research Progress on Iridiods from Lonicera Linn.

DU Fang-li,YAO Cai-yun,SONG Zhi-jun*   

  1. Guangxi Medicinal Garden,Southwest development endangered medicinal resources of national engineering laboratory,Nanning 530023,China
  • Online:2015-07-20 Published:2015-07-23

摘要: 本文主要综述了忍冬属植物中环烯醚萜类化合物的结构类型、分离方法、测试方法及其药理活性研究;由报道可知,忍冬属植物中分离得到的环烯醚萜类化合物有70多个,并且分属于三种不同的结构类型;无论属于哪种结构类型,环烯醚萜的分离方法均可概括为溶剂浸泡、萃取、柱层析细分,柱层析细分主要有反相柱层析、硅胶柱层析、凝胶柱层析。对于环烯醚萜的定性或定量测试,目前采用的主要方法是HPLC;环烯醚萜类化合物的药理活性研究目前主要集中在抗炎、止痛、解热、保肝及抗病毒方面;除此之外,文中对部分环烯醚萜化合物的生物合成途径也进行了探讨研究。

关键词: 环烯醚萜化合物, 分离方法, 测试方法, 结构类型, 药理活性

Abstract: This paper mainly described the structure types and pharmacological activities of iridoids from Genus Lonicera.,as well as their isolation and testing methods. About 70 compounds belonging to three different structures have been isolated from Lonicera plants.The separation method of iridoids can be summarized as three steps,which are solvent soaking,liquid-liquid extraction and then subjected to column chromatography on silica gel,Rp C18 reversed phase silica gel,sephadex LH-20, etc. In general,iridiods from Lonicera were detected with HPLC.With regard to the studies on pharmacological activities of iridoids,antiinflammatory,analgesia,antipyresis,liver protection and anti-virus effect were paid more attention by researchers.In addition,the biosynsesis of iridoids was also reviewed in this paper.

Key words: iridoid compounds, separation method, testing method, structure types, pharmacological activity

中图分类号: 

R932.2