关键词: 新型生物碱, 抗癌机制, 细胞凋亡, 活性氧, 端粒酶

Abstract: Alkaloids,as a natural product with high biological activities,are playing an increasingly important role in anticancer field.With the application and production of taxol and vincristine,more and more alkaloids have been found and researched.This paper reviewed several new natural alkaloids found in the recent years and illustrated the anticancer mechanism of alkaloids from the aspects of inducing cell apoptosis,regulating cell cycle,increasing reactive oxygen species (ROS),inhibiting of DNA topoisomerase,etc.

Key words: new alkaloids, anticancer, cell apoptosis, ROS, topoisomerase