植物内生菌Plantactinospora sp. NEAU-gxj3中一个新的酰胺类化合物

doi:10.16333/j.1001-6880.2016.4.002

天然产物研究与开发 ›› 2016, Vol. 28 ›› Issue (4): 481-485.doi: 10.16333/j.1001-6880.2016.4.002

植物内生菌Plantactinospora sp. NEAU-gxj3中一个新的酰胺类化合物

郭晓为1,2，张继2，李建宋2，张辉3，齐欢3，向文胜3,4，王相晶2，吴立军1*，王继栋3*

1 哈尔滨医科大学药学院，哈尔滨 150081；2 东北农业大学生命科学学院，哈尔滨 150030；3 浙江海正药业股份有限公司，台州 318000；4 中国农业科学院植物保护研究所，北京 100193

出版日期:2016-04-30 发布日期:2016-05-13

A New Amide Metabolite from Endophytic Plantactinospora sp.NEAU-gxj3

GUO Xiao-wei1,2,ZHANG Ji2,LI Jian-song2,ZHANG Hui3,QI Huan3, XIANG Wen-sheng3,4,WANG Xiang-jing2,WU Li-jun1*,WANG Ji-dong3*

1 College of Pharmacy,Harbin Medical University,Harbin 150081,China; 2 School of Life Science,Northeast Agricultural University,Harbin 150030,China; 3 Zhejiang Hisun Pharmaceutical Co.,Ltd.,Taizhou 318000,China; 4 State Key Laboratory for Biology of Plant Diseases and Insect Pests,Institute of Plant Protection,Chinese Academy of Agricultural Sciences,Beijing 100193,China

Online:2016-04-30 Published:2016-05-13

摘要/Abstract

摘要： 对植物内生菌Plantactinospora sp.NEAU-gxj3的次级代谢产物进行了研究，分离得到3个化合物，经1D和2D NMR、MS波谱分析及与文献数据的比较鉴定三个化合物分别为一个新的酰胺类化合物，(2E,7Z)-9-hydroxy-4,6,8-trimethylnona-2,7-dienamide（1）和两个已知化合物，抗生素U-62162（2）和salternamide C（3）。对三个化合物的细胞毒活性实验结果表明化合物2对人白血病细胞株K562、人肺腺癌A549细胞和人肝癌细胞株HepG2表现出较强的细胞毒活性，其IC₅₀分别为6.8、32 μg/mL和19 μg/mL。

关键词: Plantactinospora sp., 新的酰胺类化合物, 手霉素类抗生素, 抗生素U-62162, salternamide C

Abstract: A new amide metabolite,(2E,7Z)-9-hydroxy-4,6,8-trimethylnona-2,7-dienamide (1),together with two known manumycin-type compounds,antibiotic U-62162 (2) and salternamide C (3) were obtained from the fermentation broth of endophytic Plantactinospora sp.NEAU-gxj3.Their structures were determined on the basis of spectroscopic analysis,including 1D and 2D NMR as well as ESIMS and comparison with literature data.Bioassay of cytotoxic activities results showed that 2 demonstrated potent cytotoxic activity against human leukemia cell line K562,human lung adenocarcinoma cell line A549 and human liver hepatocellular carcinoma cell line HepG2 with an IC₅₀ value of 6.8,32 μg/mL and 19 μg/mL,respectively.

Key words: Plantactinospora sp., new amide metabolite, manumycin-type antibiotic, antibiotic U-62162, salternamide C

中图分类号:

R284.1 R284.2 Q93

郭晓为1,2，张继2，李建宋2，张辉3，齐欢3，向文胜3,4，王相晶2，吴立军1*，王继栋3*. 植物内生菌Plantactinospora sp. NEAU-gxj3中一个新的酰胺类化合物[J]. 天然产物研究与开发, 2016, 28(4): 481-485.

GUO Xiao-wei1,2,ZHANG Ji2,LI Jian-song2,ZHANG Hui3,QI Huan3, XIANG Wen-sheng3,4,WANG Xiang-jing2,WU Li-jun1*,WANG Ji-dong3*. A New Amide Metabolite from Endophytic Plantactinospora sp.NEAU-gxj3[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2016, 28(4): 481-485.

植物内生菌Plantactinospora sp. NEAU-gxj3中一个新的酰胺类化合物

A New Amide Metabolite from Endophytic Plantactinospora sp.NEAU-gxj3

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