胡椒酰胺类生物碱的核磁共振谱学特征

doi:10.16333/j.1001-6880.2016.8.003

天然产物研究与开发 ›› 2016, Vol. 28 ›› Issue (8): 1181-1191.doi: 10.16333/j.1001-6880.2016.8.003

胡椒酰胺类生物碱的核磁共振谱学特征

辛颖1,2#，史燕妮1,2#，朱宏涛1，王东1，杨崇仁1，许敏1,3*，张颖君1*

1 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点室，昆明 650201；2 中国科学院大学，北京 100049；3昆明理工大学生命科学与技术学院，昆明 650500

出版日期:2016-08-30 发布日期:2017-01-17

NMR Characteristics of Piper Amides

XIN Ying1,2#,SHI Yan-ni1,2#,ZHU Hong-tao1,WANG Dong1,YANG Chong-ren1,XU Min1,3*,ZHANG Ying-jun1*

1 State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China; 2 University of Chinese Academy of Sciences,Beijing 100049,China;3 Faculty of Life Science and Technology,Kunming University of Science and Technology,Kunming 650500,China

Online:2016-08-30 Published:2017-01-17

摘要/Abstract

摘要： 胡椒酰胺类生物碱是胡椒属植物的主要化学成分，结构类型多样，活性显著。自1939年首次报道以来，胡椒酰胺类生物碱一直是研究热点之一。迄今为止，已经从胡椒属植物中分离鉴定了胡椒酰胺类化合物200多个，主要涉及异丙基类、哌啶类、吡咯类等化学结构类型，且具有抗虫、抗菌、抗抑郁等生物活性。本文以胡椒属植物黄花胡椒（Piper flaviflorum）中分离得到的酰胺生物碱为例，探讨胡椒酰胺类生物碱在应用核磁共振波谱进行结构鉴定的规律。

关键词: 胡椒酰胺类生物碱, 黄花胡椒, 胡椒科, 核磁共振谱学特征

Abstract: Piper amides,with structural diversity and potential biological activities,are one of the main chemical components of Piper spp.. Since the first reported amide in 1939,piper amides have been one of the hot spots in natural products and medicinal chemistry.To date,more than 200 piper amides have been published,including isobutyl,pyrrolidine,piperidine types, etc. These amides showed insecticidal,antibacterial and antidepressive properties.Herein,the piper amides from P.flaviflorum were taken as an example to conclude the rule for structural determination of amide alkaloids by NMR data.

Key words: piper amides, Piper flaviflorum, Piperaceae NMR spectroscopic characteristics

中图分类号:

R284.2

辛颖1,2#，史燕妮1,2#，朱宏涛1，王东1，杨崇仁1，许敏1,3*，张颖君1*. 胡椒酰胺类生物碱的核磁共振谱学特征[J]. 天然产物研究与开发, 2016, 28(8): 1181-1191.

XIN Ying1,2#,SHI Yan-ni1,2#,ZHU Hong-tao1,WANG Dong1,YANG Chong-ren1,XU Min1,3*,ZHANG Ying-jun1*. NMR Characteristics of Piper Amides[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2016, 28(8): 1181-1191.

胡椒酰胺类生物碱的核磁共振谱学特征

NMR Characteristics of Piper Amides

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