关键词: 美洲大蠊, 环二肽, 一氧化氮生成, 血管生成活性

Abstract: Twenty-twocompoundswere isolatedfrom Periplaneta americana.Their structures were identified as glycerol (1),salicylic acid (2),phenylalanine (3),tryptophan (4),uracil (5),adenine (6),cyclo(Pro-Thr) (7),cyclo(Pro-Ala) (8),cyclo (Ala-Val) (9),cyclo(Gly-Ile) (10),cyclo(Gly-Leu) (11),inosine (12),adenosine (13),cyclo(Leu-Ser) (14),cyclo(Phe-Ser) (15),(3S,6S)-3-phenylmethyl-6-amidocarboxymethyl-piperazine-2,5-dione,cis-cyclo (Asn-Phe) (16),cyclo(Tyr-Gly) (17),cyclo (Tyr-Ala) (18),cyclo(Tyr-Ser) (19),cyclo(Tyr-Thr) (20),cyclo(Tyr-Asp) (21) andcordyrrole A (22),respectively,by spectroscopic methods.Compounds 20 and 21 are new naturally occurring substances.In addition,compounds 7-11 and 14-22 were isolated from the title insect species for the first time.In addition,biological evaluation towards nitric oxide (NO) production and angiogenesis activity was conducted.

Key words: Periplaneta americana, cyclic dipeptides, NO production, angiogenesis activity