关键词: 单胺氧化酶, 抑制剂, 天然产物, 抗衰老, 神经退行性疾病

Abstract: In recent years,it was widely accepted that monoamine oxidase (MAO) was an agingrelated enzyme.The MAO inhibitors had antiaging potentials.Since artificial synthesized MAO inhibitors had various side effects,it was necessary to screen safe and effective monoamine oxidase inhibitors from natural products.This paper reviewed latest research advances on the screening of monoamine oxidase inhibitors from natural products.These studies not only had practical significance for the screening and synthesis of selective MAO inhibitors,but also provided effective methods for the prevention and treatment of neurodegenerative diseases such as Alzheimer′s disease,Parkinson syndrome and depression.

Key words: monoamine oxidase, inhibitors, natural products, antiaging, neurodegenerative disease