关键词: 楝科, 望谟崖摩, 抗炎活性

Abstract: To investigate the chemical constituents and anti-inflammation from the leaves and twigs of Amoora ouangliensis,we isolated and purified the constituents from A.ouangliensis by the chromatographic technique and Semi preparation HPLC.Nine compounds were isolated,their structures were identified as cabralealactone (1),cabraleahydroxylactone (2),eichlerialactone (3),aurantiamide acetate (4),benzenepropanamide (5),xylogranatinin (6),3,5-Dimethoxy-4-hydroxybenzaldehyde (7),cycloartane-3β,24,25-triol (8) and 24(R)-19-cyclolanost-3-one-24,25-diol (9).All of the isolates were then assessed for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7.Compounds 2-4 and 9 showed protent anti-inflammatory activities.Compounds 1-9 were obtained from this plant for the first time and except compound 1,others are reported from the Amoora genus for the first time.

Key words: meliaceae, Amoora ouangliensis, anti-inflammation