关键词: 喷雾干燥, 一步制粒, 复方颗粒, Placket-burman, Box-Behnken

Abstract: In this study,to optimize one-step pelletization technology of Chinese herbal compound based on spray drying,the dry powder of compound was obtained by extraction,concentration,and spray drying.The mixture of dry powder and dextrin was used as the carrier,while some concentrated solution of compound was used as the bond.Six factors affecting one-step pelletization technology were investigated with the evaluation indexes of particle pass rate of granules,and the primal influential factors were determined by Plackett-Burman experimental design.In order to optimize one-step pelletization technology of Chinese herbal compound,the particle pass rate of granules and angle of repose of granules were used as the evaluation indexes.Then,Box-Behnken design with three levels and three factors was established.The best one-step pelletization technology process conditions were determined as follows:sample flow rate of 28 rpm,inlet air temperature of 60 ℃,wind frequency of 29 Hz,atomization pressure of 0.4 MPa,relative density of 1.15,and liquid temperature of 40 ℃.This optimized one-step pelletization technology process showed that dextrin usage was low,and the method was quality controllable,quick,and simple.

Key words: spray drying, one-step pelletization technology, Chinese herbal compound, Placket-burman, Box-Behnken