天然产物研究与开发 ›› 2019, Vol. 31 ›› Issue (增刊1): 102-107.doi: 10.16333/j.1001-6880.2019.S.018

• 开发研究 • 上一篇    下一篇

鸡矢藤不同提取工艺治疗小儿疳积的药效学比较研究

宋小仙,李恒华,吴思澜,罗金萍,李卿,涂如霞,张莉,兰波,刘剑毅*   

  1. 重庆市中药研究院 国家中医药管理局中药药理三级实验室,重庆 400065
  • 出版日期:2019-08-06 发布日期:2019-08-06
  • 基金资助:

    重庆市卫生计生委中医药科技项目(ZY20170380);重庆市科委基本科研业务费项目(cstc2018jxjl-jbky130 010;cstc2018jxjl-jbky120006;cstc2018jxjl-jbky130008)

Pharmacodynamics comparison of the different extraction processes of Paederia scandens in the treatment of infantilemalnutrition

SONG Xiao-xian,LI Heng-hua,WU Si-lan,LUO Jin-ping,LI Qing,TU Ru-xia,ZHANG Li,LAN Bo,LIU Jian-yi*   

  1. Third-level Laboratory of Pharmacology of Traditional Chinese Medicine,State Administration of Traditional Chinese Medicine,Chongqing Academy of Chinese Materia Medica,Chongqing 400065,China
  • Online:2019-08-06 Published:2019-08-06

摘要: 比较鸡矢藤不同提取工艺治疗小儿疳积的药效学差异;鸡矢藤采用水煎、水煎醇沉、醇回流三种方法制备提取物;采用小鼠厌食症模型、小鼠饮食失节脾虚模型评价鸡矢藤不同提取物治疗小儿疳积的药理作用。结果显示:鸡矢藤水煎、水煎醇沉和醇回流提取物对小鼠厌食症模型、小鼠饮食失节脾虚模型均有一定治疗作用,其中以醇回流法提取物的作用最为显著。结果表明:鸡矢藤醇回流法制备的提取物治疗小儿疳积的药效最为显著,为最佳提取工艺。

关键词: 鸡矢藤, 脾虚, 小儿疳积, 药效

Abstract: In order to compare the pharmacodynamics of different extraction processes of Paederia scandens in the treatment of infantilemalnutrition;we used three different extraction methods to prepare the experiment samples,which including water extraction,alcohol extraction and water decocted and ethanol precipitated extraction,and then evaluated the pharmacological effects of these extracts on infantilemalnutrition by using mice model of dietary disorder and mice model of spleen deficiency and anorexia.Results showed that all the three extracts of Paederia scandens had certain therapeutic effects on infantilemalnutrition,and the ethanol extracts showed the most significant effects.This study also showed that the alcohol extraction method could obtain higher extraction efficiency of active ingredients of Paederia scandens for the treatment of infantilemalnutrition.

Key words: Paederia scandens, spleen deficiency, infantilemalnutrition, pharmacological effects

中图分类号: 

R965.1