关键词: 人参皂苷, 合成途径, 转基因植物, 合成生物学, 生产工艺

Abstract: Ginsenosides,the main pharmacodynamic components of ginseng,had an excellent prospect of medical application.However,the amounts of natural ginsenosides are extremely low to meet the high demand of medical care.In recent years,with the rapid technological development in life science,researchers have characterized the key enzymes of the ginsenosides biosynthesis pathway,and have improved ginsenosides production through regulating these key enzymes by molecular biology approach.At the same time,they have introduced the key enzyme genes into tobacco and yeast cells to construct the heterology ginsenosides biosynthesis pathway for enhance the production of ginsenosides in the pharmaceutical industry.In this review,we summarized the recent researches about the key enzymes in the ginsenosides biosynthesis and ginsenosides production by latest technologies.

Key words: ginsenoside, synthetic pathway, transgenic plants, synthetic biology, production process