天然产物研究与开发 ›› 2019, Vol. 31 ›› Issue (增刊2): 84-87.doi: 10.16333/j.1001-6880.2019.S.013

• 研究简报 • 上一篇    下一篇

黄芪复方对成纤维细胞胶原蛋白和MMP的影响

王风楼1，邓文娟2，贺改英1*   

  1. 1莱博药妆技术（上海）股份有限公司，上海 201203；2无限极有限公司，广州 510000
  • 出版日期:2019-12-28 发布日期:2019-12-30

The effect of Huangqi compound on collagen and MMP in fibroblasts

WANG Feng-lou1,DENG Wen-juan2,HE Gai-ying1*   

  1. 1LB Cosmeceutical Technology Co.,Ltd,Shanghai 200233,China; 2Infinitus Company Ltd.,Guangzhou 510663,China
  • Online:2019-12-28 Published:2019-12-30

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摘要： 通过以H2O2诱导成纤维细胞造成衰老模型，观察黄芪复方对Ⅰ型和Ⅲ型胶原蛋白和细胞外基质金属蛋白酶（MMP-1和MMP -3）的影响，实验表明，H2O2显著降低了Ⅰ型和Ⅲ型胶原蛋白mRNA的表达，明显升高了MMP-1和MMP-3 mRNA的表达，黄芪复方增加了衰老成纤维细胞Ⅰ型和Ⅲ型胶原蛋白mRNA的表达，同时降低了衰老成纤维细胞MMP-1和MMP-3 mRNA的表达，研究发现黄芪复方具有延缓皮肤衰老的作用。

关键词: 黄芪复方, 成纤维细胞, Ⅰ型胶原蛋白, Ⅲ 型胶原蛋白, 细胞外基质金属蛋白酶-1, 细胞外基质金属蛋白酶-3

Abstract: The effect of Huangqi compound on collagen type I,III,extracellular matrix metalloproteinase(MMP)-1 and -3 in aging fibroblasts induced by H2O2.The experimental results showed that collagen type I and III mRNA were significantly decreased,and MMP-1 and MMP-3 mRNA was significantly increased in model group.Collagen type I and III mRNA were significantly increased by Huangqi compound in aging fibroblasts,at the same time,MMP-1 and MMP-3 mRNA were reduced.The study showed that Huangqi compound had the effect of anti-aging.

Key words: Huangqi compound, fibroblast, collagen typeⅠ, collagen type Ⅲ , extracellular matrix, metalloproteinase-1, extracellular matrix metalloproteinase-3

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