天然产物研究与开发 ›› 2020, Vol. 32 ›› Issue (增刊2): 138-143.

• 开发研究 • 上一篇    下一篇

参麦多糖口服液的制备及其抗疲劳活性探究

朱忠铠,庄宇娇,殷中琼,邹元锋*


  

  1. 四川农业大学动物医学院天然药物研究中心,成都 611130

  • 出版日期:2020-12-09 发布日期:2020-12-09
  • 基金资助:
    国家农业产业技术体系四川兽药创新团队专项(CARS-SVDIP);四川省科技厅国际合作项目(2017HH0093)

Preparation of Shenmai polysaccharide oral liquid and study on its anti-fatigue activity

ZHU Zhong-kai,ZHUANG Yu-jiao,YIN Zhong-qiong,ZOU Yuan-feng*#br#

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  1. 1 Natural Medicine Research Center,College of Veterinary Medicine,Sichuan Agricultural University,Chengdu 611130,China

  • Online:2020-12-09 Published:2020-12-09

摘要: 水提醇沉法提取得到参麦注射液中未利用到的多糖成分,通过单因素实验筛选,最终制备得到参麦多糖口服液;并将三种不同浓度多糖口服液的灌胃小鼠,探究抗疲劳活性。结果表明参麦多糖口服液的辅料为0.1%对羟基苯甲酸甲酯,0.2%羧甲基纤维素钠及2%的蜂蜜;动物实验表明参麦多糖口服液能够提高小鼠游泳时间,增加肌糖原、乳酸脱氢酶和磷酸激酶的含量,降低乳酸与尿素氮的代谢堆积。结果表明参麦多糖口服液具有抗疲劳作用。


关键词: 参麦注射液, 多糖, 口服液, 抗疲劳

Abstract:

The unused polysaccharide components in Shenmai injection were extracted by water extraction and alcohol precipitation method,and the auxiliary materials of Shenmai polysaccharide oral liquid were screened.Finally,Shenmai polysaccharide oral liquid was obtained.And three different concentrations of polysaccharide oral liquid were given to mice to explore the anti-fatigue activity.The results showed that 0.1% methyl p-hydroxybenzoate,0.2% CMC-Na and 2% honey were the auxiliary materials of Shenmai polysaccharide oral liquid.Moreover,animal experiments showed that the oral liquid could increase the swimming time,the contents of muscle glycogen,lactate dehydrogenase and phosphokinase in mice,decreased the metabolism accumulation of lactate and urea nitrogen.These results showed that Shenmai polysaccharide oral liquid had anti fatigue effect.

Key words: Shenmai injection, polysaccharide, oral liquid, anti-fatigue

中图分类号:  R932