关键词: 生物分子网络, 槲皮素, 宫颈癌, 信号通路, 靶点

Abstract: In order to study the mesh action mechanism of quercetin against cervical cancer,TCMSP,Swiss TargetPrediction,CTD,GeneCards,DisGeNET,Open Targets databases and STRING platform were used to screen and construct the network of quercetin-anticervical cancer targets and protein-protein interaction network in this study.OmicShare cloud platform was used for GO function enrichment analysis of targets.DAVID 6.8 platform was used for KEGG pathway enrichment analysis of targets.AutoDuck Vina software was used for molecular docking to analyze the affinity of quercetin and the main targets.The results showed that quercetin can act on TP53,MYC,VEGFA,STAT3,CCND1,AKT1,CASP3 and other main targets of cervical cancer,and their affinity was higher than that of the original ligands,regulate p53,Apoptosis,PI3K-Akt,Jak-STAT and other signaling pathways,these targets and signaling pathways can block the process of cervical cancer cell cycle,and induce its apoptosis,resist tumor angiogenesis and other multiple anticancer mechanisms.quercetin can be further studied as potential therapeutic drug for cervical cancer.

Key words: biomolecular network, quercetin, cervical cancer, signal pathway, target