天然产物研究与开发 ›› 2020, Vol. 32 ›› Issue (增刊1): 7-11.doi: DOI:10.16333/j.1001-6880.2020.S.001

• 研究论文 • 上一篇    下一篇

基于网络药理学预测甘草泻心汤加减味治疗前列腺癌的潜在靶点及其机制研究

陈萧月1，胡斌2，朱国华2，朱建国2*


  

  1. 1贵州大学医学院，贵阳 550025；2贵州省人民医院，贵阳 550002

  • 出版日期:2020-06-28 发布日期:2020-07-20
  • 基金资助:
    贵州省科技计划（黔科合支撑［2019］2799号，黔科合平台人才［2017］5803）；国家自然科学基金面上项目（81873608）

Prediction of potential targets and mechanisms of Gancaoxiexin Decoction in treating prostate cancer based on network pharmacology

CHEN Xiao-yue1,HU Bin2,ZHU Guo-hua2,ZHU Jian-guo2*   

  1. Prediction of potential targets and mechanisms of Gancaoxiexin Decoction in treating prostate cancer based on network pharmacology

  • Online:2020-06-28 Published:2020-07-20

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摘要： 基于网络药理学，初步探讨预测甘草泻心汤加减味治疗前列腺癌的潜在靶点及其机制研究。应用在线数据库TCMSP筛选出本处方7味中药潜在活性成分，通过Drugbank和STITCH数据库分析筛选药物靶点，从TTD和DisGeNET数据库查询前列腺癌疾病靶点，分别采用Venn图合并，利用STRING数据库构建靶蛋白相互作用网络，同时利用STRING和DAVID数据库进行GO富集分析和KEGG信号通路的富集。本研究共筛选到170个潜在活性成分和与疾病映射后的60个靶点蛋白。处方中药物的活性成分主要作用于PTGS2、ESR1、AR、PPARG等靶蛋白，调控MAPK信号通路、VEGF信号通路和Apoptosis凋亡通路，发挥治前列腺癌作用。综上所述，甘草泻心汤加减味可以通过阻滞细胞周期抑制细胞增殖、抑制新血管生成和促进细胞死亡的多靶点-多通路干预治疗前列腺癌。

关键词: Gancaoxiexin Decoction, network pharmacology, prostate cancer, cell cycle, potential target

Abstract:

To predict the potential targets and mechanisms of Gancaoxiexin Decoction in the treatment of prostate cancer based on network pharmacology.The TCMSP database was used to screen out the potential active ingredients of the traditional Chinese medicines in this prescription.And the targets of herbs were analyzed and screened by the Drugbank and STITCH databases.The treatment targets of prostate cancer were screened from the TTD and DisGeNET databases.Combined the two results via Venny chart to obtained the intersection,the PPI database was used to construct the interactive target regulation function of Gancaoxiexin Decoction and prostate cancer.At the same time,the DAVID and STRING analysis platform was used for GO analyses and enrichment of KEGG signaling pathways.In this study,170 potential active ingredients and 60 target proteins mapped to disease were screened.The active ingredients of the drug in the prescription mainly act on PTGS2,ESR1,AR,PPARG and other target proteins,which regulates the MAPK signal pathway,VEGF signal pathway and apoptosis apoptotic pathway,and play a crucial role in treating prostate cancer.In conclusion,Gancaoxiexin Decoction can treat prostate cancer by multi-target and multi-pathway interventions that arrest cell cycle,inhibit cell proliferation,inhibit neovascularization and promot cell death.

Key words: Gancaoxiexin Decoction, network pharmacology, prostate cancer, cell cycle, potential target

中图分类号:  R285

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