天然产物研究与开发 ›› 2022, Vol. 34 ›› Issue (1): 153-163.doi: 10.16333/j.1001-6880.2022.1.019

• 综述 • 上一篇    下一篇

岩藻多糖的提取、化学改性、降血糖活性及机理研究进展

陈舒桐1,2,3,4，俞珵1,2,3,4，李瑞1,2,3,4*，钟赛意1,2,3,4   

  1. 1广东海洋大学食品科技学院；2广东省海洋生物制品工程实验室；3广东省海洋食品工程技术研究中心；4广东省水产品加工与安全重点实验室，湛江 524008
  • 出版日期:2022-01-28 发布日期:2022-01-28
  • 基金资助:
    广东省大学生创新创业训练计划（S20201056022）；广东省自然科学基金面上项目（2021A1515010868）；广东省普通高校特色创新项目（自然科学）（2020KTSCX 051），广东省高等学校科技创新团队项目（2021KCXTD021）

Research progress on extraction,chemical modification and hypoglycemic property and mechanism of fucoidans

CHEN Shu-tong1,2,3,4,YU Cheng1,2,3,4,LI Rui1,2,3,4*,ZHONG Sai-yi1,2,3,4   

  1. 1College of Food Science and Technology,Guangdong Ocean University;2Guangdong Province Engineering Laboratory for Marine Biological Products;3Guangdong Provincial Engineering Technology Research Center of Marine Food;4Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety,Zhanjiang 524008,China
  • Online:2022-01-28 Published:2022-01-28

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摘要： 岩藻多糖（fucoidans，FU）主要来源于海洋褐藻和海洋无脊椎动物，是一种复杂的硫酸化多糖。FU主要单糖组成为岩藻糖，含有大量硫酸基团，是一种多聚阴离子同型杂多糖。FU具有广泛的潜在健康功效及治疗作用，包括抗肿瘤、调节免疫、抗病毒、降血糖等。FU的化学结构及硫酸基团含量对功能活性具有重要影响，不同提取方法影响FUs的结构组成，而化学改性可以进一步提高其生物活性。因此，本文旨在概述FU的提取、化学改性方法及降血糖活性和机理，展望了FU提取、化学改性、结构及降血糖活性及其他生物活性构效关系方面未来研究方向，为今后的加工和创新利用提供理论参考。

关键词: 岩藻多糖, 提取, 化学改性, 降血糖活性, 降血糖机理

Abstract:

Fucoidans derive from marine brown algae and marine invertebrates,and they are complex sulphated polysaccharides. Fucoidans contain a simple structure mainly composed of fucose units and a large number of sulfate groups and they are polyanion heteropolysaccharides.Fucoidans have a wide range of potential health effects and therapeutic effects,including anti-tumor,immune regulation,anti-virus,hypoglycemia,etc.The chemical structure and sulfate group contents of fucoidans have important effects on their functional activities.Different extraction methods affect the structural composition of fucoidans,and chemical modification can further improve their biological activities.Therefore,this paper aims to summarize the extraction and chemical modification methods,hypoglycemic activity and mechanism of fucoidans,and to predict the future prospects of the research direction of extraction,chemical modification,the structure-activity relationship between fucoidans and hypoglycemic activity and other biological activities,so as to provide theoretical reference for the processing and innovative utilization of fucoidans.

Key words: fucoidans, extraction, chemical modification, hypoglycemic property, hypoglycemic mechanism

中图分类号:  TS254.5

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