Comprehensive quality evaluation of salt-processed Plantaginis Semen based on HPLC-QAMS multi-index components quantitative determination combined with chemometrics and entropy weight-technique for order preference by similarity to an ideal solution(EW-TOPSIS) method,which provided reference for scientific evaluation of salt-processed Plantaginis Semen quality and determination of suitability for producing area.A total of 18 samples from five provinces were collected.Using verbascoside as an internal standard,determination of aucubin,geniposidic acid,10-hydroxy majoroside,plantamajoside, verbascoside,isoacteoside,quercetin,kaempferol,luteolin and apigenin in salt-processed Plantaginis Semen by HPLC-QAMS.Chemometrics method were used to comprehensively analyze the content determination results,and the main potential markers affecting the quality of salt-processed Plantaginis Semen were excavated.The quality of salt-processed Plantaginis Semen from different origins was evaluated.The ten components showed good linear relationships within their respective ranges,and accuracy was good.There was no significant difference in the determination results of QAMS method and external standard method (ESM) (P>0.05).The chemometrics method showed that 18 batches of salt-processed Plantaginis Semen could be clustered into three categories,showing certain regional differences.verbascoside,geniposidic acid,apigenin and plantamajoside were the main potential markers affecting the quality of chaperone fruit,Results of entropy weight TOPSIS method showed that the quality of salt-processed Plantaginis Semen in Jiangxi the best in all provinces,followed by Henan,Anhui,Shandong and Guangxi.The established HPLC-QAMS method is convenient and accurate,and combined with chemometrics and EW-TOPSIS method can be used for the comprehensive evaluation of the quality of salt-processed Plantaginis Semen.