The paper mainly studies the changes of 5 heavy metal residues in the rhizosphere soil,fibrous roots and rhizome of Paris polyphylla var. yunnanensis inoculated with different arbuscular mycorrhizal fungi (AMF) mixed inoculants,which provides a reference for the research and development of biological bacterial fertilizer.Effects of inoculating different AMF mixed inoculants in sterilized soil on the residues of 5 heavy metals (Pb,Cu,As,Hg and Cr) in the rhizosphere soil,fibrous roots and rhizomes (new rhizomes and old rhizomes) of Paris polyphylla var. yunnanensis were studied through a pot inoculation experiments.The results showed that,compared with control,exogenous inoculation of different AMF mixed inoculants promoted the increase of the above five heavy metal residues in fibrous roots,and significantly reduced the residues of the above five heavy metals in the rhizosphere soil and rhizomes (new rhizomes and old rhizomes) of Paris polyphylla var. yunnanensis. Among them,S6 mixed inoculants (Claroideoglomus claroideum,Septoglomus deserticola,Scutellospora pellucida,Scutellospora calospora, Gigaspora gigantea and Gigaspora margarita) had the best regulation effect on the residues of heavy metals in the rhizosphere soil and rhizomes of Paris polyphylla var. yunnanensis.The heavy metal residues in the rhizosphere soil were reduced by 11.32%,16.73%,54.53%,52.33% and 30.44%.The heavy metal residues in new rhizomes were reduced by 23.43%,51.65%,15.04%,29.74% and 29.66%.The heavy metal residues in old rhizomes were declined by 40.13%,39.14%,30.99%,44.86% and 37.91%.It can be seen that exogenous inoculation of AMF mixed inoculants can significantly reduce the enrichment ability in rhizomes of Paris polyphylla var. yunnanensis to 5 kinds of heavy metal elements.Among them,S6 mixed inoculants can be used as a reference for reducing the accumulation of heavy metals during field cultivation of Paris polyphylla var. yunnanensis.