To provide reference for the formulation of quality standards of Lobeliae Chinensis Herba formula granules and related preparations,the transmission law of quantity value of Lobeliae Chinensis Herba standard decoction was studied.Twenty-one batches of Lobeliae Chinensis Herba decoction pieces were made into standard decoction.Paste yield and extracts were measured.The fingerprints of Lobeliae Chinensis Herba decoction pieces and standard decoction were established.Through similarity evaluation and chemometric analysis,the change rules of common peaks from decoction pieces to standard decoction were studied.The contents of diosmin and linarin were measured and the transfer rates were calculated.The results showed that paste yield of 21 batches of Lobeliae Chinensis Herba ranged from 29.91% to 47.94% and the extracts ranged from 22.19%-36.36%.Eleven identical common peaks were identified in the fingerprints of Lobeliae Chinensis Herba decoction pieces and standard decoction,indicating that the common peaks can be transferred from the decoction pieces to the standard decoction.The overall similarity of the fingerprint of the decoction pieces was relatively high,while the similarity of the standard decoction varied greatly.Principal component analysis (PCA) showed that 21 batches of decoction pieces and standard decoction were classified into one group respectively.Five chromatographic peaks with significant changes in relative peak area were found by orthogonal partial least squares discriminant analysis (OPLS-DA).The content range of diosmin in 21 batches of standard decoction was 0.15-0.54 mg/g and the transfer rate range was 1.53%-4.99%.The content range of linarin was 0.06-0.15 mg/g and the transfer rate range was 4.27%-8.98%.This study can provide a certain reference for the formulation of quality standards of Lobeliae Chinensis Herba formula granules and related preparations.