天然产物研究与开发 ›› 2023, Vol. 35 ›› Issue (5): 787-797.doi: 10.16333/j.1001-6880.2023.5.007

• 研究简报 • 上一篇    下一篇

千里香化学成分研究

王茹茹,张珊珊,许红涛,王永丽,侴桂新*   

  1. 上海中医药大学中药研究所,上海 201203
  • 出版日期:2023-05-26 发布日期:2023-05-26
  • 基金资助:
    重大新药创制科技重大专项子课题(2019ZX09735002-004)

Chemical constituents of Murraya paniculata (L.) Jack.

WANG Ru-ru,ZHANG Shan-shan,XU Hong-tao,WANG Yong-li,CHOU Gui-xin*   

  1. Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China
  • Online:2023-05-26 Published:2023-05-26

摘要: 研究千里香的化学成分。采用硅胶、ODS、Sephadex LH-20、制备液相等多种色谱分离技术进行分离纯化,通过波谱数据分析进行结构鉴定。从千里香70%乙醇提取物中分离得到26个化合物,分别鉴定为千里香脂素(1)、8-去甲基川陈皮素(2)、ficusal(3)、lariciresinol-4′-monomethy ether(4)、(±)-5′-methoxy-4′-O-methyllariciresinol(5)、diospyrosin(6)、(-)-9′-O-E-feruloyl-lyoniresinol(7)、7-O-methylphellodenol-B(8)、欧芹烯酮酚甲醚(9)、3,4′-二羟基-3′,5′-二甲氧基苯丙酮(10)、4′-羟基-5,7-二甲氧基二氢黄酮(11)、5-羟基-6,7,3′,4′-四甲氧基二氢黄酮(12)、4′-羟基-5,7,3′-三甲氧基二氢黄酮(13)、5,7,3′,4′,5′-五甲氧基二氢黄酮(14)、2′,4-二羟基-3′,4′,6′-三甲氧基查尔酮(15)、2′,3-二羟基-4,4′,6′-三甲氧基查尔酮(16)、楝叶吴萸素B(17)、2′-羟基-3,4,5,4′,6′-五甲氧基查尔酮(18)、2′-羟基-3,4,4′,6′-四甲氧基查尔酮(19)、5,8-二羟基-6,7,3′,4′-四甲氧基黄酮(20)、3′-羟基-5,6,7,8,4′,5′-六甲氧基黄酮(21)、5,3′,5′-三羟基-7,4′-二甲氧基黄酮(22)、5,7,3′-三羟基-8,4′-二甲氧基黄酮(23)、3′-羟基-5,6,7,4′-四甲氧基黄酮(24)、5,7,3′,4′,5′-五甲氧基黄酮(25)、5-羟基-6,7,8,3′,4′-五甲氧基黄酮(26),其中化合物12为新化合物,化合物3~810~13151620~24为首次从九里香属植物中分离得到,化合物17为首次从千里香中分离得到。

关键词: 千里香, 化学成分, 木脂素, 黄酮, 香豆素

Abstract: To study the chemical constituents of Murraya paniculata (L.) Jack, two new compounds, named as murrayanin (1) and 8-demethylnobiletin (2), along with twenty-four known compounds (3-26) were isolated from the 70% EtOH extract of M. paniculata by various chromatographic techniques such as silica gel, ODS, Sephadex-LH 20, Pre-HPLC, their structures was elucidated by spectral data analysis. The known compounds were identified as ficusal (3),lariciresinol-4′-monomethy ether (4),(±)-5′-methoxy-4′-O-methyllariciresinol (5),diospyrosin (6),(-)-9′-O-E-feruloyl-lyoniresinol (7),7-O-methylphellodenol-B (8),osthenon (9),3,4′-dihydroxy-3′,5′-dimethoxyphenylacetone (10),4′-hydroxy-5,7-dimethoxyflavanone (11),cystosiphonin (12),4′-hydroxy-5,7,3′-trimethoxyflavanone (13),5,7,3′,4′,5′-pentamethoxyflavanone (14),2′,4-dihydroxy-3′,4′,6′-trimethoxychalcone (15),2′,3-dihydroxy-4,4′,6′-trimethoxychalcone (16),evofolin B (17),2′-hydroxy-3,4,5,4′,6′-pentamoxychalcone (18),2′-hydroxy-3,4,4′,6′-tetramethoxychalone (19),5,8-dihydroxy-6,7,3′,4′-tetramethoxyflavone (20),3′-hydroxy-5,6,7,8,4′,5′-hexamethoxyflavone (21),5,3′,5′-trihydroxy-7,4′-dimethoxyflavone (22),5,7,3′-trihydroxy-8,4′-dimethoxyflavone(23),8-hydroxy-5,6,7,3′,4′-pentamoxyflavone (23),3′-hydroxy-5,6,7,4′-tetramethoxyflavone (24),5,7,3′,4′,5′-pentamethoxyflavone (25) and 5-hydroxy-6,7,8,3′,4′-pentamethoxyflavone (26),respectively.Compounds 3-8,10-13,15,16,20-24 were obtained from the genus Murraya for the first time,and compound 17 were isolated from M. paniculata for the first time.

Key words: Murraya paniculata (L.) Jack., chemical constituent, lignan, flavone, coumarin

中图分类号:  R932