To explore the interaction between vitamin D(Vit D) and chronic kidney disease (CKD)based on network pharmacology,and to explore the core proteins that affect the common targets of vitamin D and CKD.Two targets of Vit D were obtained through the DrugBank database.A total of 1 074 targets of CKD disease were obtained through DisGeNET database.The intersection of Vit D targets and the targets of CKD was obtained by the Venny platform. A common target of Vit D and CKD was obtained,which was VDR.The common targets were imported into the String database to construct the protein-protein interaction (PPI) network,and the core proteins of protein-protein interaction were screened.PPI network analysis showed that ten proteins were the main proteins affecting the action of VDR,which were GC,CYP27B1,EP300,NCOA3,CTNNB1,MED1, SMAD3,RXRA,BAZ1B,NCOA1.Based on the results of network pharmacology,Vit D may play a role in the prevention or treatment of CKD by acting on the VDR targets.GC,CYP27B1,EP300,NCOA3,CTNNB1,MED1,SMAD3,RXRA,BAZ1B and NCOA1 could interact with VDR,and affect the core protein of the common target of Vit D and CKD.