天然产物研究与开发 ›› 2024, Vol. 36 ›› Issue (7): 1142-1148.doi: 10.16333/j.1001-6880.2024.7.005

• 研究论文 • 上一篇    下一篇

肉桂叶化学成分研究

张亚伦1，朱研洁1，代向阳1，王小兰1，郝志友1，孙彦君1，冯卫生1,2*，陈  辉1,2*   

  1. 1河南中医药大学药学院；2呼吸疾病中医药防治省部共建协同创新中心，郑州 450046
  • 出版日期:2024-07-28 发布日期:2024-07-26
  • 基金资助:
    国家自然科学基金面上项目（22177027）；河南省高校科技创新团队支持计划（24IRTSTHN039）；河南省科技研发计划联合基金（优势学科培育类）（232301420067）

Chemical constituents from the leaves of Cinnamomum cassia

ZHANG Ya-lun1,ZHU Yan-jie1,DAI Xiang-yang1,WANG Xiao-lan1,HAO Zhi-you1,SUN Yan-jun1,FENG Wei-sheng1,2*,CHEN Hui1,2*
  

  1. 1School of Pharmacy,Henan University of Chinese Medicine;2Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Disease by Henan & Education Ministry of China,Zhengzhou 450046,China
  • Online:2024-07-28 Published:2024-07-26

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摘要：

为研究肉桂（Cinnamomum cassia Presl）叶的化学成分，采用大孔树脂、ODS、硅胶柱色谱及半制备高效液相等色谱分离技术对肉桂叶正丁醇萃取部位进行分离纯化。共从中分离得到8个化合物，根据其理化性质及波谱数据进行结构鉴定，分别为(7S,8S)-4,9,7′-trihydroxy-3,3′,5′-trimethoxy-8-O-4′-neolignan 7-O-β-D-glucopyranoside（1）、蚱蜢酮（2）、柑橘苷A（3）、loliolide-β-D-glucopyranoside（4）、methyl dihydromelilotoside（5）、methyl 2-phenylpropanoate-2-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside（6）、2,3-dihydroxy-1-(4-hydroxyl-3,5-dimethoxyphenyl)-1-propanone（7）、4-O-(2-hydroxy-1-hydroxymethylethyl)-dihydroconiferyl alcohol（8）。化合物1为新的苯丙素葡萄糖苷，化合物3~5、7、8为首次从该植物中分离得到。采用HepG2细胞胰岛素抵抗模型对化合物1~8进行体外降血糖活性筛选，结果显示，在10.0 μmol/L 浓度下，化合物2、3、7和8可以增加胰岛素抵抗HepG2细胞的葡萄糖消耗量。

关键词: 肉桂叶, 化学成分, 酚苷类, 降血糖活性

Abstract:

This study aims to investigate the chemical constituents of the leaves of Cinnamomum cassia. The extract of the leaves of C. cassia was separated and purified utilizing chromatographic techniques including macroporous resin,ODS,silica gel column chromatography and semi-preparative high performance liquid phase.Eight compounds were isolated from the n-butanol fraction of the leaves of C. cassia,and their structures were identified as (7S,8S)-4,9,7′-trihydroxy-3,3′,5′-trimethoxy-8-O-4′-neolignan7-O-β-D-glucopyranoside (1),grasshopper ketone (2),citroside A (3),loliolide-β-D-glucopyranoside (4),methyl dihydromelilotoside (5),methyl 2-phenylpropanoate-2-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside (6),2,3-dihydroxy-1-(4-hydroxyl-3,5-dimethoxyphenyl)-1-propanone (7),4-O-(2-hydroxy-1-hydroxymethylethyl)-dihydroconiferyl alcohol (8).Among them,compound 1 is a new phenylpropanoid glucoside,and compounds 3-5,7,and 8 were isolated from the plant for the first time.Compounds 2,3,7 and 8 could significantly increase the glucose consumption in insulin-resistant HepG2 cells at a concentration of 10.0 mol/L.

Key words: leaves of Cinnamomum cassia, chemical constituents, phenolic glycosides, hypoglycemic activity

中图分类号:  R284.2

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