天然产物研究与开发 ›› 2024, Vol. 36 ›› Issue (增刊2): 131-142.

• 综述 • 上一篇    下一篇

伊贝母化学成分及药理作用的研究进展

董元秋,雷   婷,张进强*   

  1. 贵州中医药大学,贵阳 550025
  • 出版日期:2024-12-09 发布日期:2024-12-09
  • 基金资助:
    中央本级重大增减支项目(2060302)

Research progress on chemical compositions and pharmacological effects of Fritillariae Pallidiflorae Bulbus

DONG Yuan-qiu,LEI Ting,ZHANG Jin-qiang*   

  1. Guizhou University of Traditional Chinese Medicine,Guiyang Guiyang 550025,China
  • Online:2024-12-09 Published:2024-12-09

摘要: 伊贝母为百合科植物新疆贝母或伊犁贝母的干燥鳞茎,主产于新疆。具有清热润肺,化痰止咳的功效,临床上常用于治疗肺热燥咳,干咳少痰,阴虚劳嗽,咳痰带血等症状。伊贝母中含有多种活性成分,目前鉴定了108种,其结构类型多样,包括生物碱类36种、甾体皂苷类16种、甾体糖生物碱类5种、多糖类7种、香豆素类4种、核苷类4种、有机酸及酯类化合物21种及其他类化合物15种。这些成分具有祛痰、平喘、镇咳、抗肿瘤、抗氧化、抗菌、抗炎、神经保护等多种药理活性。本文对伊贝母的化学成分及药理作用研究现状进行了综述,以期对伊贝母化学成分和药理作用的认识及研究提供参考,为药材的深度开发和利用提供依据。

关键词: 伊贝母, 中药材, 化学成分, 药理活性, 化痰止咳

Abstract:

Fritillariae Pallidiflorae Bulbus is the dried bulb of Fritillaria walujewii or F. pallidiflora,which is mainly produced in Xinjiang.It has the effect of clearing heat and moisturizing the lung,resolving phlegm and relieving cough.It is often used in the clinical treatment of lung heat dry cough,dry cough with less phlegm,Yin deficiency and cough with blood and other symptoms.There are a variety of active ingredients in the Fritillariae Pallidiflorae Bulbus,108 chemical compounds,including 36 alkaloids,16 steroidal saponins,5 steroidal glycoalkaloids,7 polysaccharides,4 coumarins,4 nucleosides,21 organic acids and esters,and 15 other compounds were identified.These ingredients has expectorant,and asthma,cough,anti-tumor,antioxidant,antibacterial,anti-inflammatory,nerve protection and so on the many kinds of pharmacological activities.This article reviews the research status of chemical components and pharmacological effects of Fritillariae Pallidiflorae Bulbus,in order to provide reference for the understanding and research of chemical components and pharmacological effects of Fritillariae Pallidiflorae Bulbus,and provide basis for the in-depth development and utilization of medicinal materials.

Key words: Fritillariae Pallidiflorae Bulbus, traditional Chinese medicine, chemical constituents, pharmacological effects, Dispel phlegm and relieve cough

中图分类号:  R932