天然产物研究与开发 ›› 2016, Vol. 28 ›› Issue (4): 575-578.doi: 10.16333/j.1001-6880.2016.4.019

• 研究简报 • 上一篇    下一篇

大黄酚复合物的制备方法研究

李红1,吴振2*,陈岗2,詹永2,谭红军2   

  1. 1 重庆市食品药品检验检测研究院,重庆401121;2 重庆市中药研究院,重庆 400065
  • 出版日期:2016-04-30 发布日期:2016-05-13

Preparation of Inclusion Complex of Chrysophanol

LI Hong1,WU Zhen2*,CHEN Gang2,ZHAN Yong2,TAN Hong-jun2   

  1. 1 Chongqing Institute for Food and Drug Control,Chongqing 401121,China; 2 Chongqing Academy of Chinese Materia Medica,Chongqing 400065,China
  • Online:2016-04-30 Published:2016-05-13

摘要: 为提高大黄酚(Chr)的水溶性和生物利用度,旨在找出一种适合大黄酚-β-葡聚糖超分子复合物(Chr-β-glu)的制备方法,为制剂加工和贮存研究提供依据。分别采用饱和溶液法、共研磨法、冷冻干燥法、电磁搅拌喷雾干燥法(ES)和共沉淀法等方法制备Chr-β-glu,以包封率、渗漏率和累积释放率为评价指标,选出最适合Chr-β-glu的制备方法。电磁搅拌-喷雾干燥法处理可以显著提高大黄酚-β-葡聚糖超分子包合物的平均包封率和累积释放率,明显优于其他方法;共沉淀法制备的Chr-β-glu的平均渗漏率最低,但与ES法制备相比没有显著性差异。采用电磁搅拌喷雾干燥法制备的大黄酚-β-葡聚糖超分子包合物具有较高的包封率和稳定性,作为药物载体,其在医药、食品和日化工业中具有广泛的应用前景。

关键词: 大黄酚, 葡聚糖超分子复合物, 制备方法, 电磁搅拌-喷雾干燥法, 包封率

Abstract: To improve the solubility and bioavailability of chrsophanol (Chr) and provide the foundation for preparation,processing and storage of new formulations,five preparation methods of supermolecular inclusion complex of Chr and -β-glucan (Chr-β-glu) were compared.The inclusion complex of Chr-β-glu prepared by saturated solution method,co-grinding method,freeze drying method,electromagnetic stirring-spray drying (ES) method and co-precipitation method,respectively,was compared based on the index of encapsulation efficiency,percolation rate and cumulative release rate.The results showed that the encapsulation efficiency and cumulative release rate of Chr-β-glu prepared by ES method was higher than samples prepared by other preparation methods.The percolation rate of Chr-β-glu prepared by co-precipitation method was lower than samples prepared by other preparation methods.However,the percolation rate was of no significant difference between ES method and co-precipitation method.The supermolecular inclusion complex of Chr and -β-glucan had higher encapsulation efficiency and better stability.It will be widely applied in medicinal,food and daily chemical industries.

Key words: chrsophanol, glucan-supermolecular inclusion, preparation methods, electromagnetic stirring-spray drying methods, encapsulation efficiency

中图分类号: 

R932 TS201.2