天然产物研究与开发 ›› 2016, Vol. 28 ›› Issue (7): 1024-1028.doi: 10.16333/j.1001-6880.2016.7.007

• 研究论文 • 上一篇    下一篇

VBE-1经皮渗透行为的考察及其对紫外线诱导皮肤色素沉着的干预作用

李溯1,王婷2,丁劲松3*   

  1. 1 中南大学湘雅医院药学部,长沙 410008;2 湖南省儿童医院药学部,长沙 410007;3 中南大学药学院,长沙 410013
  • 出版日期:2016-07-30 发布日期:2017-01-17

Transdermal Behavior of VBE-1 and Its Interference Effect on Skin Pigmentation of Guinea Pig Induced by Ultraviolet B Irradiation

LI Su1,WANG Ting2,DING Jin-song3*   

  1. 1 Department of Pharmacy,Xiangya Hospital,Central South University,Changsha 410008,China; 2 Department of Pharmacy,Hunan Children's Hospital,Changsha 410007,China; 3 Department of Pharmaceutics,School of Pharmaceutical Sciences,Central South University,Changsha 410013,China
  • Online:2016-07-30 Published:2017-01-17

摘要: 采用Franz扩散池考察溶液和混悬液的体外经皮渗透特性,计算混悬液和溶液中VBE-1的渗透动力学参数,并测定VBE-1在皮肤中的滞留量。溶液中VBE-1的稳态渗透速率显著提高,渗透时滞明显缩短,24 h单位质量皮肤累积滞留量提高了35%,VBE-1的经皮渗透行为得到了优化。制备VBE-1凝胶,选用棕黄色豚鼠为动物模型,考察VBE-1对紫外线诱导皮肤色素沉着的干预作用,结果显示2% VBE-1凝胶组的皮肤黑色素增加量明显低于空白基质组。VBE-1在较高浓度时对紫外线诱导的皮肤色素沉着有一定的干预作用。

关键词: VBE-1, 经皮渗透特性, 滞留量, 黑色素, 棕黄色豚鼠

Abstract: The transdermal permeation characteristics of VBE-1 in solution and suspension were investigated by Franz-type diffusion cell in vitro. The permeation and skin residual amount of VBE-1 were quantified by HPLC,and permeation kinetics parameters were calculated.The lag time was shortened and 24 h skin residual amount was increased by 35% in solution.Transdermal behavior of VBE-1 was optimized.Brownish guinea pig model was used to study the interference effect of VBE-1 gel on skin pigmentation induced by ultraviolet B(UVB)irradiation.The results showed that skin melanin increment of 2% VBE-1 gel was significantly lower than the gel base group.The UVB irradiation induced skin hyperpigmentation was interfered by VBE-1 at higher concentrations.

Key words: VBE-1, transdermal behaviors, skin residual amount, melanin, brown guinea pig

中图分类号: 

R944.9