关键词: 丹酚酸A, 化学相似性搜索, 酪氨酸蛋白激酶, 靶蛋白

Abstract: Salvianolic acid A (SAA) is a water-soluble component from Danshen.It plays many pharmacological roles in many diseases treatments with its potentialantioxidant activity.But its targets is still need to be illustrated.In this study,SwissTargetPrediction server was used to identify the potential targets of SAA by chemical similarity searching.The results showed that Src tyrosine family protein,such as Fyn and Src,may be the targets of SAA.Moreover,docking results showed SAA can interact with key residues of Fyn.In conclusion,Src tyrosine family protein,such as Fyn and Src,may be the potential targets of SAA.

Key words: salvianolic acid A, chemical similarity searching, tyrosine family protein, target protein