天然产物研究与开发 ›› 2016, Vol. 28 ›› Issue (10): 1612-1617.doi: 10.16333/j.1001-6880.2016.10.021

• 开发研究 • 上一篇    下一篇

96种中药单体抑制血管生成的活性研究

花慧1，张敏2，陶永辉3*   

  1. 1 泰州学院医药与化学化工学院，泰州 225300；2 无锡卫生高等职业技术学校，无锡 214062；3江苏省血吸虫病防治研究所 卫生部寄生虫病预防与控制技术重点实验室 江苏省寄生虫分子生物学重点实验室，无锡 214064
  • 出版日期:2016-10-31 发布日期:2017-03-30

Anti-angiogenesis Effects of 96 Compounds from Chinese Medicine

HUA Hui1,ZHANG Min2,TAO Yong-hui3*   

  1. 1 College of Pharmacy and Chemistry & Chemical Engineering,Taizhou University,Taizhou 225300,China; 2Wuxi Higher Health Vocational Technology School,Wuxi 214028,China;3Jiangsu Institute  of Parasitic Diseases,Key Laboratory of Parasitic Disease Control and Prevention (Ministry of Health), Jiangsu Provincial Key Laboratory of Parasite Molecular Biology,Wuxi 214064，China
  • Online:2016-10-31 Published:2017-03-30

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摘要： 采用内皮细胞高通量筛选模型和鸡胚尿囊膜（CAM）实验筛选技术，分析96种中药单体的抑制血管生成的活性。筛选结果表明有11种中药单体对Eahy-926细胞的增殖有一定的抑制作用且呈剂量依赖关系，有10种中药单体具有抑制CAM血管形成的作用。秦皮素、汉防己甲素、和厚朴酚、蝙蝠葛碱、鲁斯可皂苷元、高粱姜素、染料木素、隐绿原酸、齐墩果酸和α-倒捻子素，这10种单体化合物值得进一步研究。

关键词: 中药单体, 高通量筛选模型, Eahy 926细胞

Abstract: 96 Compounds from Chinese medicine were assayed against Eahy-926 cell in vitro and 11 of them on the chorioallantoic membrane (CAM) in vivo. The results showed that 11 compounds had a dose-dependent inhibition of growth in Eahy-926 cells in vitro, and 10 of them significantly inhibited angiogenesis on CAM at a concentration of 50 μg/egg.Compounds fraxetin,tetrandrine,honokiol,dauricine,ruscogenin,galangin,genistin,4-dicaffeoylquinic acid,oleanolic acid and α-mangostin showed anti-angiogenesis activity,and were worth further studying.

Key words: compounds from Chinese medicine, high throughput screening, Eahy-926 cell

中图分类号: 

R287

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