关键词: 海洋真菌, 内生真菌, Aspergillus fumigatus, 代谢产物, 生物碱

Abstract: In order to find new,potentially biologically active compounds from marine microorganisms,we investigated the metabolites of an endophytic fungus named Aspergillus fumigatus, which was separated from Coelarthrum boergesenii (collected from Paracel Islands in South China Sea).Accordingly,16 compounds were isolated from the EtOAc-soluble portion of the fermentation broth of Aspergillus fumigatus. On the basis of extensive spectroscopic analyses (1D and 2D NMR,HR-ESI-MS) and by comparison with the spectroscopic data in the published literature,they were determined as gliotoxin (1),bis (dethio)bis (methylsulfanyl)gliotoxin（2）,fumiquinazoline C (3),(-)-chaetomium (4),verruculogen (5),fumitremorgin C (6),brevianamide F (7),fumigaclavine C (8),decanedioic acid,2-methylene (9),2-methylene,1-methyl ester (10),2-undecenedioic acid (11),2-undecenedioic acid,1-methyl ester (12),decanedioic acid,helvolic acid (13),and di-2-ethyl hexyl phthalate (14),physcion (15),emodin (16),respectively.Among them,compounds 9,10 and 12 are new natural products.

Key words: thalassiomycetes, endophytic fungi, Aspergillus fumigatus, metabolites, alkaloids